Associate Engineer, RNA Starting Material MS&T

Sarepta Therapeutics Andover, MA May 16, 2026

$62K - $78K

Position Overview The Associate Engineer, RNA Starting Material MS&T will work in a team focused on lab‑scale organic synthesis, purification, analysis, and characterization of the nucleoside‑based and lipid building blocks used in Sarepta’s PMO and siRNA platforms. The role involves synthesis of reference markers/standards, participation in supervised RNA starting materials manufacturing process chemistry development, and scale‑up projects to optimize and troubleshoot syntheses. The position involves cross‑functional training, regular interaction with Analytical/QC resources, and interpretation of HPLC, GC, KF, and NMR data. It also requires protocol and report writing and excellent organic chemistry and problem‑solving skills. Responsibilities Support commercial supply assurance for RNA starting materials by synthesizing nucleoside reference markers/standards. Execute development studies independently or as part of a team under supervision. Assess scalability of proposed changes and execute experiments to mimic large‑scale impacts. Participate in the technology transfer of improved processes to manufacturing sites. Cultivate a firm scientific understanding of Sarepta’s manufacturing processes to support process improvements, troubleshooting, and technology transfers. Perform synthesis and purification (chromatography) of nucleoside analogs to support both production and development goals. Contribute to collaborative efforts to characterize and manage impurity profiles of intermediates. Use scientific judgement to determine likely source and fate of newly identified impurities and design experiments to test hypotheses as part of a cross‑functional team. Compile, interpret, document, and present study results. Participate in vendor update meetings and provide input on ongoing vendor production projects. Qualifications B.S. (required) in Chemical Engineering, Chemistry, or related discipline, 0–2 years of related experience. Technical competence in organic chemistry and familiarity with analyzing and interpreting data from GC, LC‑MS, HPLC, NMR, and KF instrumentation; experience running HPLC methods is strongly preferred. Ability to handle a multi‑task workload and perform effectively under deadlines. Effective written and verbal communication skills. Strong interpersonal skills and attention to detail. May require less than 5% infrequent domestic and/or international travel. Location & Compensation This position requires on‑site work at one of Sarepta’s facilities in the United States. The targeted salary range for this position is $62,000–$77,500 per year. Benefits Sarepta offers a competitive compensation and benefit package designed to support employees in all aspects of their lives. Legal Notice Candidates must be authorized to work in the U.S. Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e‑Verify. #J-18808-Ljbffr Dormont Manufacturing Co