Grad Co-op - Protein Design for Target Discovery

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity‑related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award‑winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Grad Co-op – Protein Design for Target Discovery What You Will Do During this program, you will conduct state of the art research in protein design for target discovery. Responsibilities include: Identify and catalog genetic variants that result in gain or loss of post‑translational modifications (PTMs) on therapeutically relevant cell surface proteins. Apply computational and AI‑based approaches to model the structural impact of PTM gain/loss on protein epitopes and therapeutic target accessibility. Design and optimize binders against disease‑relevant epitopes exposed by loss of PTM. Apply laboratory binder discovery and characterization workflows to validate lead binders. Design and execute laboratory experiments to characterize binder specificity, target engagement, and functional activity. Collaborate with computational and experimental scientists to communicate research findings. What We Expect of You We are all different, yet we all use our unique contributions to serve patients. The individual we seek is an independent and proactive scientist with these qualifications: Basic Qualifications: 18 years or older Graduated with a bachelor’s degree from an accredited college or university Currently enrolled in an MBA program for an MBA internship OR a Master’s program for a Master’s internship OR a PharmD program for a PharmD internship OR Ph.D. for a PhD internship from an accredited college or university and completion of the first year of MBA OR Master’s OR Pharm D OR Ph.D. program before the internship starts Enrolled in an accredited college or university following the potential internship or co‑op assignment Must not be employed at the time the internship starts Student must be located in the United States for the duration of the co‑op Preferred Qualifications: Currently pursuing a PhD in Computational Biology, Bioengineering, Biochemistry, Computer Science, or a related field. Experience with programming in Python and/or R. Strong analytical, problem‑solving, and communication skills. Experience with protein engineering, structural biology, computational protein design, or antibody discovery. Familiarity with AI/ML approaches for protein modeling and binder design. Experience with molecular dynamics simulations or protein structure prediction tools. Experience in conducting biochemical experiments in a research laboratory. Prior research experience in computational and/or experimental biological sciences. What You Can Expect of Us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well‑being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The base pay range for this opportunity in the U.S. is $30 - $40 per hour. Build a network of colleagues that will endure and grow throughout your time with us and beyond. Bring your authentic self to the table and become the professional you’re inspired to be through accepting a culture that values the diversity of thought and experience and will flex to your strengths and possibilities. Participate in executive and social networking events, as well as community volunteer projects. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. #J-18808-Ljbffr Amgen SA