Executive Director, GCS Kidney — POVE

Job Description General Summary:

The Executive Director, Global Commercial Strategy (GCS) Kidney - Pove will be the senior commercial leader for povetacicept across the kidney indications, including immunoglobulin A nephropathy (IgAN) and primary membranous nephropathy (pMN). The role will own the global commercial strategy for the kidney franchise, supporting the near-term U.S. launch and subsequent global launches in IgAN while advancing pMN toward commercialization. The Executive Director will co-lead the povetacicept Kidney Program Team with the Development Lead, guiding program strategy and key development, lifecycle, and investment decisions. The role will lead global launch execution and lifecycle management in IgAN and build the global commercialization and launch strategy for pMN.

Key Duties & Responsibilities

Co-lead the povetacicept Kidney Program Team with the Development Lead, setting the integrated strategy, priorities, and decision framework across IgAN and pMN.

Own the global commercial strategy for povetacicept in kidney, connecting launch, lifecycle, development, evidence, and investment priorities across the franchise.

Lead GCS support for the U.S. IgAN launch and subsequent global launches, ensuring clear strategy, critical success factors, regional alignment, readiness, and execution.

Own global lifecycle management for povetacicept in IgAN, identifying and advancing opportunities to strengthen differentiation, expand patient impact, generate evidence, and maximize long-term value.

Lead the global commercialization and launch strategy for pMN, including market development, positioning, target product profile, evidence needs, value proposition, launch sequencing, and readiness.

Shape development plans and lead commercial development activities across IgAN and pMN, including market research, forecasting, competitive intelligence, scenario planning, evidence requirements, and business cases.

Build deep understanding of the IgAN and pMN markets, patients, treatment pathways, competition, access dynamics, and requirements for success.

Ensure alignment between the kidney strategy and broader povetacicept portfolio, partnering with GCS leaders for non-kidney indications while maintaining clear accountability by vertical.

Partner across Development, Medical, Regulatory, Value & Access, Finance, Manufacturing, and regional Commercial teams to deliver a globally aligned strategy and launch plan.

Communicate clear recommendations to senior leaders and governance bodies, identifying key uncertainties, trade-offs, risks, and actions required.

Build and lead a high-performing kidney commercial team as the franchise advances.

Required Education Level

Minimum of a Bachelor's degree in business, marketing, life sciences, healthcare, or a related field.

Advanced degree such as an MBA, M.S., Pharm.D., Ph.D., or M.D. preferred.

Required Experience

Extensive biopharmaceutical commercial experience, including global commercial strategy, new product planning, or marketing leadership.

Demonstrated experience leading global launch strategy and execution for specialty or rare disease products.

Strong experience in lifecycle management, commercial development, forecasting, evidence strategy, and investment decision-making.

Launch or development experience in nephrology, specialty, rare disease, immunology, or other complex markets; direct kidney experience strongly preferred.

Experience leading cross-functional teams in a matrixed environment; program-team leadership experience preferred.

Exceptional strategic thinking, analytical rigor, business judgment, communication, and influencing skills.

Proven people leadership and ability to build collaborative, high-performing teams.

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range: $260,600 - $390,800 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation

Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as:

• 1. Hybrid: work remotely up to two days per week; or select
• 2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law.

Vertex is an E-Verify Employer in the United States.

Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at View email address on click.appcast.io.

Help Us Achieve Our Mission

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1.

Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East.

Vertex is consistently recognized as one of the industry's top places to work, including 17 consecutive years on Science magazine's Top Employers list and one of Fortune's 100 Best Companies to Work For.

For company updates and to learn more about Vertex's history of innovation, visit or follow us on LinkedIn, Facebook, Instagram, YouTube, and X.

We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.