Senior/Principal Scientist - Synthetic Molecule Analytical Chemistry, Genentech Research and Early Development (South San Francisco)

The PositionWe advance science so that we all have more time with the people we love.A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Genentech!The Opportunity:We are seeking a highly motivated Senior Scientist or Principal Scientist with a strong record of laboratory innovation and technical depth to join our Synthetic Molecule Analytical Chemistry (SMAC) group.This role is ideal for a scientist who thrives at the bench and is excited to solve complex analytical challenges, while contributing to advancing programs spanning discovery through clinical development.The Scientist will play a key role in advancing a diverse pipeline including synthetic small molecules, peptides, oligonucleotides, and drug delivery systems (e.g., lipid nanoparticles, polymer nanoparticles), working in a highly collaborative, cross-functional environment:Designing, developing, and troubleshooting analytical methods from first principles, including sample preparation, method optimization, and data interpretation with state-of-the-art technologies including but not limited to high resolution mass spectrometry (HRMS), UHPLC, 2D-LC/MS, GC/MS, light scattering, spectroscopy, rheology, microscopy.Applying and deepen expertise in HRMS, MS/MS, and/or chromatographic separations to solve complex analytical problems during drug discovery/development.Contributing to regulatory submissions, including authoring sections and preparing data packages for health authority interactions.Partnering with cross-functional teams (process development, formulation, safety science, quality, etc.) to develop control strategies aligned with cGMP, ICH, and regulatory expectations.Informing program decisions across discovery and early development, i.e. generating high-quality data to guide molecular and formulation decisionsInnovating and evaluating new technologies in analytical chemistry or materials characterization to enable the integration of state-of-the-art instrumentation and software to solve complex problems.Maintaining a high-level scientific profile both internally and externally in terms of pipeline contributions and scholarly achievements.Who You Are:Successful candidates will possess the following qualifications:PhD in Analytical Chemistry, Pharmaceutical Sciences, Materials Sciences, Bioengineering, or relevant scientific disciplines with 0-2 years industry experience ( Senior Scientist); 3-5 years of industry experience (Principal Scientist). Exceptional candidates with Bachelor or Master degree in these fields with 12+ years of experience may be considered. Title and level will be aligned with qualifications and experience.Outstanding record of innovation and success in multiple projects over the course of graduate, post-doctoral and industrial career with a sustained publication or patent record.Deep hands-on expertise in at least one of the following areas for the analysis of synthetic small molecules, peptides, oligonucleotides, polymers, or nanoparticles (lipid and polymer nanoparticles) is required:Mass spectrometry method development (HRMS, MS/MS, structural elucidation)Chromatographic method development (reversed phase, normal phase, HILIC, SEC, SFC, 2D-LC/MS)Experience with chromatography and/or MS data systems (e.g., Empower, Xcalibur, MassHunter, Chromeleon), and ability to independently analyze complex datasets, is required.Excellent communication (orally and in writing) and organizational skills.Ability to collaborate, learn, and eventually lead in a CMC/cross functional environment.Ability to take initiative, think strategically, work in teams and develop people, have advanced literature searching and problem-solving skills.Preferred:Exposure to CMC, regulatory submissions, or analytical control strategies.Working knowledge of data analysis, modeling, and AI assisted workflows, including the ability to effectively use AI tools (e.g., LLM).Relocation benefits are available for this posting.The expected salary range for this position based on the primary location of California for Senior Scientist is $124,300- $230,900 and Principal Scientist is $143,200-$265,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.BenefitsGenentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.Job SummaryJob number: 202603-107743Date posted : 2026-07-21Profession: Research & DevelopmentEmployment type: Full time