Principal/Sr. Principal Scientist - Development (South San Francisco)

The PositionThe Department of Translational Safety at Genentech provides scientific leadership and plays an active role in the process of drug development from the discovery phase through marketed products. We are seeking a Principal/Sr Principal Scientist in Toxicology to support drug development. This role will involve working in a collaborative team environment as part of the comprehensive safety assessment of Genentech therapeutics by providing toxicology representation to programs.The successful candidate for Principal/Sr Principal Scientist will provide scientific leadership and play an active role in the process of drug development, with a strong emphasis on Genentech’s oncology and cardiovascular, respiratory, and metabolism development project portfolio, which includes small molecules, immunomodulatory biotherapeutics, bi-specific antibodies, ADCs, cancer vaccines and cellular therapeutics.Working in a collaborative team environment, the Principal/Sr Principal Scientist leads the safety assessment of Genentech therapeutics by creating a best-evidence synthesis of existing knowledge and comprehensive investigations of toxicologic activity, strategic planning, and designing/implementing/supervising toxicology studies in support of program advancement.The OpportunityInterdisciplinary project team membershipScientific leadership in the design and implementation of safety assessment strategies to support program advancement and decision-makingPreparation and review of regulatory documentationPreparation and review of study reports and manuscriptsRepresentation of Genentech in meetings with regulatory authoritiesInvestigations into mechanisms of toxicityProactive management of potential safety liabilities and communication of impact to teams and governance committees.Experience with cross-functional teams and capability to build productive cross-functional internal and external collaborations are desired.Mentoring of toxicologists and as needed, team members, and lead or provide support to inter- and intra-departmental initiatives.Who You ArePrincipal ScientistPhD and post-doctorate or equivalent experience in toxicology or a relevant field along with a minimum of 3+ years relevant experience in the pharmaceutical/biotechnology/CRO industry related to toxicology.Extensive experience in drug development and interaction with global regulatory authorities are required.Experience in oncology and cardiovascular, respiratory, and metabolism therapy areas leveraging different therapeutic modalities such as small molecules, degraders, and ADCs is highly desirableEvidence of a consistent and extensive record of impact internally and externally.The successful candidate must also demonstrate strong decision-making, complex problem solving, critical data analysis and interpretation, excellent written and verbal communication skills; and the ability to build productive cross-functional collaborations both within and external to GenentechBoard certification in toxicology is desirable.The expected salary range for this position based on the primary location of California is $141,500 - $262,900. Senior Principal ScientistPhD and post-doctorate or equivalent experience in toxicology or a relevant field along with a minimum of 8+ years relevant experience in the pharmaceutical/biotechnology/CRO industry related to toxicology.Extensive experience in drug development and interaction with global regulatory authorities are required.Experience in oncology and cardiovascular, respiratory, and metabolism therapy areas leveraging different therapeutic modalities such as small molecules, degraders, and ADCs is highly desirableEvidence of a consistent and extensive record of impact internally and externally.The successful candidate must also demonstrate strong decision-making, complex problem solving, critical data analysis and interpretation, excellent written and verbal communication skills; and the ability to build productive cross-functional collaborations both within and external to GenentechBoard certification in toxicology is desirable.The expected salary range for this position based on the primary location of California is $171,110 and $321,490Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.BenefitsLocationsThis position is based in San Francisco. This role is primarily onsite.Relocation benefits are available.Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.Job SummaryJob number: 202606-114872Date posted : 2026-06-24Profession: Research & DevelopmentEmployment type: Full time