Principal Scientist, Synthetic Molecule Process Chemistry, Genentech Research (South San Francisco)

The PositionA healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Genentech!The OpportunityGenentech is seeking a top-tier Principal Scientist in Chemistry with a proven record of sustained laboratory achievement and innovation to join our Synthetic Molecule Process Chemistry group. The Scientist, leading from the bench as part of our project-based research and development staff, is responsible for:Developing enabling chemistry during early and/or late stage research in support of early development-readiness decisionsDeveloping processes to manufacture Active Pharmaceutical Ingredient (API) in early development through Phase III route selectionDelivering API supply in early phase clinical developmentUsing the enabling chemistry developed, the Scientist, working with our South San Francisco clinical manufacturing team, will participate in the production of early phase GMP clinical supplies. Eventual route selection for late stage GMP API manufacturing is also the responsibility of the Scientist and includes the concepts of safe, efficient, robust, environmentally sound chemistry and extends to the synthesis of the regulatory starting materials and establishment of a robust supply chain. A key job requirement is the ability to interact closely with discovery chemists and sourcing partners throughout development. The Scientist is expected to maintain a high level scientific profile both internally and externally in terms of scholarly achievements and pipeline contributions.The successful candidate will be responsible for developing processes suitable for controlling the quality of bulk API as required by cGMP, ICH and FDA regulations as well as the bulk attributes conducive to successful formulation development. In addition, writing relevant CMC sections of INDs and participating in developing a strategy for quality are important tasks. The position's mission will be accomplished through innovation and teamwork, collaboration with strategic partners, creative problem solving and use of state-of-the-art technology.Who You AreSuccessful candidates will possess the following qualifications:PhD in highly relevant scientific discipline with 0-3 years industry experience.Outstanding record of innovation and success in multiple projects over the course of their graduate, post-doctoral and industrial career with a sustained publication record.Strong working knowledge of the latest developments in contemporary synthetic organic and/or process chemistry including chemo- and bio-catalysis, organometallic chemistry as well as expertise in asymmetric transformations, heterocyclic chemistry, and/or peptide chemistry.Ability to interact, learn and eventually lead in a CMC/cross functional environment.Ability to take initiative, provide strategic input, problem solve, work in teams, develop people and communicate clearly, both orally and in writing.PreferredDemonstrated experience at the kilogram delivery scale is preferred.Relocation benefits are available for this posting.Applicants are requested to submit a short Research Summary in addition to their CV.The expected salary range for this position based on the primary location of California is $144,900 to $269,100. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.Benefits#LI-KC2Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.Job SummaryJob number: 202607-117903Date posted : 2026-07-10Profession: Research & DevelopmentEmployment type: Full time