Senior Manager, Portfolio Management & Operations

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: Revolution Medicines is seeking a motivated individual with experience in CMC, project and portfolio management, and/or life sciences management consulting to play a critical role within the Portfolio Management group of the Pharmaceutical Development and Manufacturing (PDM) organization. This position will serve as a key business partner supporting portfolio analytics, governance operations, resource and cost management, and strategic cross‑functional initiatives. The role will partner closely with cross‑functional stakeholders to drive execution of critical business processes, support decision‑making, and improve organizational effectiveness across a growing portfolio of discovery, development, and commercial programs. Responsibilities: Partner with PDM leadership and cross‑functional stakeholders to support portfolio planning, business operations, and strategic decision‑making across the organization. Develop analyses, insights, and recommendations that enable effective prioritization, resource allocation, risk management, and execution of business objectives. Drive cross‑functional planning and governance activities by facilitating stakeholder alignment, supporting decision‑making forums, and ensuring effective follow‑through on key actions and commitments. Develop and maintain portfolio reporting, metrics, dashboards, and other decision‑support tools to provide visibility into portfolio performance, organizational capacity, risks, and opportunities. Support budgeting and long‑range planning activities through data analysis, scenario modeling, and business insight generation. Lead or contribute to strategic initiatives and operational excellence efforts aimed at improving business processes, organizational effectiveness, and scalability. Apply structured problem‑solving and analytical approaches to address complex cross‑functional challenges and support informed decision‑making. Build strong partnerships across PDM and adjacent functions to promote transparency, alignment, and effective execution of key priorities. Prepare and deliver clear, concise, and compelling communications, presentations, and recommendations for audiences ranging from working teams to senior leadership. Required Skills, Experience and Education: B.Sc. in a scientific, engineering, business, or related discipline, with 5+ years of experience within a CMC, Project and Portfolio Management, and/or life sciences management consulting organization. Robust analytical and problem‑solving skills with experience in scenario planning, forecasting, resource modeling, and business analytics; demonstrated ability to translate analytical insights into executive‑level communications. Strong scientific and business acumen with the ability to connect data, portfolio priorities, resource constraints, and organizational objectives into actionable recommendations. Demonstrated intellectual curiosity and learning agility, with a willingness to quickly develop expertise in new business processes, functional areas, and technical domains. Ability to influence without authority and build productive working relationships across functions and organizational levels. Exceptional communication and storytelling skills with the ability to synthesize complex information into clear, concise, and compelling recommendations for senior leadership. Demonstrated ability to balance strategic thinking with operational execution and deliver results across complex cross‑functional initiatives. Demonstrated success operating in fast‑paced, dynamic environments with evolving priorities and ambiguity. Proven track record of taking ownership, identifying opportunities for improvement, and proactively driving solutions with minimal direction. Strong project management and facilitation skills with the ability to drive alignment, manage competing priorities, and execute effectively in ambiguous environments. Preferred Skill: Advanced degree in a scientific, engineering, business, or related discipline. PMP or similar project management certification. #LI-CT1 #LI-Hybrid The base pay salary range for this full‑time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job‑related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal‑opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact View email address on click.appcast.io. Base Pay Salary Range

$164,000 — $205,000 USD

We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message. Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address. If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to View email address on click.appcast.io so we can share these impersonations with our IT team for tracking and awareness. #J-18808-Ljbffr Revolution Medicines