Sr Principal Engineer - MES Systems

Job ID: R-104429Company: LillyLocation: Richmond, Virginia, United States of AmericaJob Type: Full TimeCategory: Information TechnologyPosted Date: 2026-06-09At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.Sr Principal Engineer – MES SystemsAt Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.This is an opportunity you don’t want to miss!Lilly is entering an exciting period of growth and we are committed to delivering innovative medicines to patients around the world. Lilly is investing over $50 Billion to create new Manufacturing Capacity throughout the world. This is an exciting once-in-a-lifetime opportunity to help build and start up new sites. What You’ll Be DoingThe Sr Principal Engineer - MES System will part of one of our new state of the art API facility MES team tasked with developing standard approaches and components that will used to build MES recipes and integration throughout Lilly’s network of new Active Pharmaceutical Ingredients (API) sites. The role will assist local teams in the Design, Development, Delivery and CSV of the MES solutions for the new facilities. This role will report to the MQ IT Leader for new facilities.What You Should Bring (preferred skills)Pharmaceutical Manufacturing Regulatory compliance knowledge and experience (cGMP)Effective people and team leadership skillsAbility to manage and contribute to multiple concurrent activities and adapt to changes in priorities.Ability to cross functionally collaborate.Excellent written and oral communication skills.Demonstrate creativity, analytical thinking, and the ability to troubleshoot and solve problems.Knowledge of cloud solutions and architectureHistory of promoting safety and maintaining a safe work environmentEstablish a strong site culture based in Lilly values, expectations, and operational excellence standards.Demonstrated adhere adherence to compliance for internal and external quality guidance.Demonstrated and promote Operational ExcellenceEffectively encourage knowledge sharing and educationEvaluate and translate functional requirements into technical solutions.Ability to problem solving and work through manufacturing situations. Have experience serving as an escalation contact with vendor(s)Proven technical ability to develop and integrate MES solutionsWhat Your Primary Responsibilities Will Be:Develop and integrate MES common and site-specific components. Benchmark on innovative solutions (external and internal to Lilly)Dynamically adapt road map to site evolution/strategic directions, and new trends/issues.Establish a strong site culture based in Lilly values, expectations, and operational excellence standards.Support MES solutions start up activities.Work with site resources towards replication & standardization to drive value and implement the appropriate technical solutions.Evaluate emerging technologies and implications to existing Lilly footprint.Maintain open communication with MES vendor(s) to address needs in standard solution or via functional packs.Evaluate and translate functional requirements into technical solutions.Ensure project and/or validation documentation is maintained during lifecycle & release management.Develops \ assists in the creation and maintenance of the MES interfaces with other Lilly systems.Your Basic Qualifications (with no sponsorship)Bachelor’s Degree in IT, Engineering, or related technical field,10+ years of strong experience with MES system implementations and Data Integration preferably Syncade/Delta V MESProfessional experience working in a GXP, regulated environmentOther Information:Role is Monday through Friday and based on-site. Must be flexible in providing support to accommodate other inputs (production schedules, shutdowns, etc.). Occasional extended hour and / or off-hour work may be required.Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form () for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is$126,000 - $184,800Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.#WeAreLillySkillsmes system implementationdata integrationsyncadedelta v mescloud solutions architecturegxp complianceoperational excellencevalidation documentationproject documentationvendor managementstakeholder management