Senior Technical Operations Manager

When our people share why they joined Rapport and love it here, it comes down to three things: the science, the mission, and the team. At Rapport, we’re driven by a passion for developing precision neuromedicines with the potential for fewer side effects, enabling patients and their families to enjoy healthier, more fulfilling lives. And we’re doing this with extraordinary science and awesome people (affectionately called Rapptors). Our innovative scientific platform is centered on Receptor Associate Proteins (RAPs). RAPs are a component of neuronal receptor complexes, which play a crucial role in regulating receptor assembly and function. This precision approach has the potential to revolutionize the development of small molecule therapies. We are excited about the potential of our lead program, RAP-219. Our first indication targets focal epilepsy with additional clinical trials for neuropathic pain and bipolar disorder. The strength of Rapport comes from our Rapptors – who are united by our mission to improve patients lives. We bring the heart and hustle to advance our science forward, always staying true to our core values. We hope you’re as excited about this opportunity as we are! This role is based in Boston, MA with onsite presence required Monday-Wednesday Your impact: The Senior Technical Operations Manager plays a critical role in driving cross-functional execution across CMC (Chemistry, Manufacturing & Controls), Supply Chain, Quality, and Toxicology to advance small molecule programs from early development through late-stage clinical development and NDA submission. This role combines program management with operational logistics, ensuring alignment of timelines, deliverables, and resources across internal teams and external partners. The ideal candidate will bring strong CMC program management expertise, operational rigor, and the ability to proactively identify and mitigate risks across drug substance and drug product development activities, including outsourced manufacturing and nonclinical support. Your day-to-day: Program Operations & Logistics Coordinate cross-functional program execution across CMC, Quality, Supply Chain, and Toxicology Maintain integrated development plans, timelines, and program documentation Track key milestones, risks, action items, and support program communications Coordinate logistics for raw materials, API, drug product, and clinical/nonclinical supplies, including inventory, shipments, and documentation Ensure operational readiness to support regulatory milestones and development activities Vendor & Supply Chain Management Coordinate CDMO and CRO activities to support program timelines and deliverables Support SOW execution, vendor performance tracking, and budget management Partner with Finance and functional teams to monitor program expenditures Collaborate with Quality to ensure compliant material handling, distribution, and supply continuity Must-Haves: Bachelor's degree in a life sciences, engineering, supply chain, or related field 5+ years of experience in CMC operations, supply chain, logistics, or project management within the biotechnology or pharmaceutical industry. Demonstrated experience managing complex logistics, including material planning, inventory, vendor coordination, and time-sensitive shipments. Highly organized with exceptional attention to detail and the ability to manage multiple priorities across cross-functional teams. Experience working with CDMOs, CROs, and external vendors in a regulated GMP/GxP environment. Strong project management and communication skills with a proven ability to track timelines, risks, budgets, and deliverables. Proficiency with Microsoft Office (Excel, PowerPoint, Project) and document management/project tracking systems. Ability to work independently in a fast-paced, dynamic environment while maintaining a high level of accuracy and accountability. What makes Rapport special: Every role has meaning. We’re determined to discover a better way for patients, and you’ll feel the passion from the start. We are driven to innovate. Exciting science that pushes boundaries and opens new possibilities. Your perspective matters. Stick your neck out, share your ideas – we work as a team. We have FUN. We hire smart, dedicated, down-to-earth people that you’ll enjoy spending time with. Leadership that CARES – about you, your growth + development. We're bicoastal. Whether you're in the lab full-time in San Diego or taking advantage of a more hybrid work schedule in Boston – we make the most of our time together. Competitive benefits. Including unlimited PTO, a lifestyle spending account, commuting reimbursement, and much more! You get to be YOU! Show up as you are and make every day count. Your Compensation: We get it. Compensation is an important part of your offer. You shouldn’t be surprised at the end of the recruiting process, and you should know that your offer is fair and equitable. How do we do this? We tell you about our hiring range now - we expect the hiring range for the role to be $175,000 to $195,000. Our actual offer will reflect a lot of factors including your relevant skills, experience, location, salary market data, and internal equity. In addition to a competitive salary, we also offer a pretty great benefits package. We don’t stop here - if you join Rapport, we go to the next level. We share our full salary ranges for every level across our company. Hybrid Work Environment: We prioritize in person connection with our fellow Rapptors! Our team members come together onsite at our Boston office Monday-Wednesday to create more opportunities for innovation, collaboration, and connection. Rapport Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited. CCPA disclosure notice can be found here.