Research Scientist/Engr 3
$80.24kFHLB Des Moines
- # Research Scientist/Engr 3Applylocations: Seattle, WAtime type: Full timeposted on: Posted Todaytime left to apply: End Date: August 21, 2026 (7 days left to apply)job requisition id: REQ-0000135125**Job Description****Department of Biochemistry has an outstanding opportunity for Research Scientist/Engineer 3 to join their** **team.****About this Opportunity**This interdisciplinary role operates at the intersection of de novo protein design, regenerative medicine, and synthetic biology. By integrating AI-guided computational protein engineering with genomics and molecular biology, the position aims to decode and manipulate the cellular signaling pathways that govern stem cell identity, tissue development, and aging.**Purpose of the research project(s) this position supports:**To develop transformative, AI-driven protein technologies that enable precise, programmable control over cellular identity and function. By engineering de novo signaling molecules and synthetic regulatory systems, these projects aim to orchestrate cell fate specification, transdifferentiation, vascular regeneration, and tissue repair. This work bridges fundamental developmental biology with translational engineering, establishing versatile therapeutic modalities designed to restore damaged tissues and reverse historically intractable human diseases.**Duties and Responsibilities:**1. Computational Protein Design & Engineering (30%)Architect, model, and optimize novel signaling proteins ("Novokines") utilizing state-of-the-art, AI-guided de novo design suites (e.g., RFdiffusion, ProteinMPNN, and AlphaFold-based structure prediction).Iterate and refine designs based on empirical wet-lab feedback to maximize binding specificity, potency, and pathway selectivity.2. Experimental Validation in Stem Cell & Aged Fibroblast Systems (25%)Cultivate, differentiate, and immunophenotypically characterize stem cells and aged fibroblasts to evaluate Novokine-mediated cell-state transitions, including lineage specification, transdifferentiation, and vascular morphogenesis.Orchestrate and execute robust functional assays, including reporter assays, lineage tracing, and downstream signaling pathway readouts.3. Genomic & Systems-Level Analysis (15%)Execute and analyze transcriptomic, epigenomic, and single-cell sequencing (scRNA-seq) workflows to map the molecular mechanisms driving engineered cell-fate transitions.Integrate multi-omic datasets to uncover predictive biological insights, refining iterative protein design architectures.4. Data Science & Systems Biology Modeling (10%)Deconstruct complex experimental and sequencing datasets using advanced statistical techniques; deploy or build computational systems biology models to decipher signaling network dynamics.5. Scientific Communication, Manuscripts, & Grants (10%)Draft and co-author high-impact manuscripts for peer-reviewed publication.Contribute technical writing and preliminary data visualization to grant proposals, progress reports, and abstract submissions for national/international conferences.6. Mentorship & Interdisciplinary Collaboration (5%)Provide technical mentorship to junior trainees, graduate students, and research technicians in computational workflows and molecular biology techniques.Manage collaborative data and reagent exchanges with cross-functional internal and external academic/industry partners.7. Regulatory Compliance & Laboratory Governance (5%)Maintain meticulous records within electronic laboratory notebooks (ELNs).Ensure strict adherence to institutional biosafety, IACUC, and IRB protocols.**Required Qualifications**To be considered for this opportunity your application must demonstrate you meet both the minimum qualifications and additional qualifications listed below. Equivalent education and/or experience may substitute for minimum qualifications except when there are legal requirements, such as a license, certification, and/or registration.**Minimum Requirements:****Applicants who do not meet these qualifications WILL NOT be forwarded to the Hiring Department.**Bachelor's Degree in Molecular and Human Genetics and 4 years of experience in cell and molecular biology.**Additional Requirements:**1. Strong foundational knowledge in molecular and cellular biology, including gene expression, protein function, and signal transduction pathways. 2. Experience with standard laboratory techniques such as mammalian cell culture, molecular cloning, plasmid construction, and transfection/transduction methods. 3. Familiarity with protein expression systems, protein purification approaches, and/or biochemical assay development. 4. Experience or strong interest in AI-assisted protein engineering, including de novo protein design, computational protein modeling, and structure-guided design approaches. 5. Experience with AI/ML-based protein–protein interaction prediction methods, including network inference, structural modeling, or sequence-based interaction prediction approaches. 6. Familiarity with computational or statistical approaches for cell state identification, including analysis of single-cell or high-dimensional data (e.g., clustering, trajectory inference, or classification of cellular states). 7. Ability to design, execute, and troubleshoot experiments independently with strong attention to detail and reproducibility. 8. Experience with microscopy-based assays and quantitative image analysis (preferred). 9. Working knowledge of basic data analysis and visualization tools (e.g., GraphPad Prism, R, or Python preferred). 10. Understanding of experimental design, statistical analysis, and proper controls in biological experiments. 11. Strong organizational skills, including maintaining accurate laboratory records and documenting experimental workflows. 12. Ability to work collaboratively in a multidisciplinary team environment and communicate results effectively. 13. Strong written and verbal communication skills for presenting data, preparing reports, and contributing to manuscripts or grant-related documents. 14. Ability to learn new techniques quickly and adapt to evolving research priorities in a fast-paced research environment.**Preferred Qualifications****:**1. Strong background in AI/ML-based de novo protein design, protein–protein interaction prediction, including sequence-based modeling, structural docking approaches, or network-based inference methods. 2. Experience with computational biology approaches for cell state identification, including single-cell RNA-seq analysis, clustering, trajectory inference, and classification of heterogeneous cellular populations. 3. Experience in transdifferentiation.**Visa Sponsorship:**This recruitment is open to applicants who will require employer sponsorship for an H-1B or E-3 visa.**Compensation, Benefits and Position Details****Pay Range Minimum:**$80,244.00 annual**Pay Range Maximum:**$82,800.00 annual**Other Compensation:**-**Benefits:**For information about benefits for this position, visit Shift (United States of America)**Temporary or Regular?**This is a regular position**FTE (Full-Time Equivalent):**100.00%**Union/Bargaining Unit:**UAW Research**About the UW**Working at the University of Washington provides a unique opportunity to change lives – on our campuses, in our state and around the world.UW employees bring their boundless energy, creative problem-solving skills and dedication to building stronger minds and a healthier world. In return, they enjoy outstanding benefits, opportunities for professional growth and the chance to work in an environment known for its diversity, intellectual excitement, artistic pursuits and natural beauty.**Our Commitment**The University of Washington is committed to fostering an inclusive, respectful and welcoming community for all. As an equal opportunity employer, the University considers applicants for employment without regard to race, color, creed, religion, national origin, citizenship, sex, pregnancy, age, marital status, sexual orientation, gender identity or expression, genetic information, disability, or veteran status consistent with UW Executive Order No. 81.To request disability accommodation in the application process, contact the Disability Services Office at View phone number on click.appcast.io or View email address on click.appcast.io considered for this position will be required to disclose if they are the subject of any substantiated findings or current investigations related to sexual misconduct at their current employment and past employment. Disclosure is required under Washington state law.
- J-18808-Ljbffr FHLB Des Moines
Vacancy posted 2 days ago
Similar jobs that could be interesting for youBased on the Research Scientist/Engr 3 in Seattle, WA vacancy
$99.44k
## Research Scientist/Engr 4Applylocations: Seattle, WAtime type: Full timeposted on: Posted 13 Days Agojob requisition id: REQ-0000129345**Job Description****Field of research:**Single particle cryo-electron microscopy and X-ray crystallization of viral glycoproteins,...SuggestedFull timeTemporary workShift workFHLB Des Moines
Seattle, WA3 hours ago$80.24k
...DescriptionThe Department of Genome Sciences’ Northwest Genomics Center (NWGC) (Wei Lab) has an outstanding opportunity for a Research Scientist 3, Genomics, to join the team.About this OpportunityReporting to the NWGC Director of Operations, the Research Scientist 3...SuggestedFull timeTemporary workH1bWork at officeWorldwideShift work$80.24k
Job DescriptionThe Division of Metabolism, Endocrinology and Nutrition (MET) has an outstanding opportunity for a Research Scientist/Engineer 3 position to support studies within the Pyle and Bjornstad Laboratories.Housed within the University of Washington Medicine Diabetes...SuggestedFull timeTemporary workTraineeshipWork at officeShift work$88.8k
...of Hematology & Oncology has an outstanding opportunity for a Research Scientist to join their Cancer Vaccine Institute (CVI) team.About this OpportunityReporting... ...at the Cancer Vaccine Institute (CVI), the Research Scientist 3 is responsible for promoting the research objectives of the...SuggestedFull timeTemporary workTraineeshipWork at officeFlexible hoursShift workAfternoon shift$56.45k
Field of Research Protein engineering, synthetic biology, and biochemical tool development with emphasis on optogenetically controlled RNA/DNA polymerases, programmable nucleic‑acid writing, and in vitro assay systems for polymerase activity, specificity, and error control...SuggestedTraineeshipInternshipH1bWork at officeShift workDay shift$148.5k - $225k
...we will want to talk to you.Chewy's Supply Chain is seeking a Research Scientist III of a balanced background in optimization and machine learning... ...in cloud environments like AWS, Azure, Google cloud, etc.3+ years industry experience on solving business problem in partnership...Work experience placementLocal areaFlexible hours- ...and processes based on the IT Infrastructure Library (ITIL) v.3 Framework across enterprise infrastructure operations. These... ...CMMI-DEV Level 3"Job DescriptionWe are looking for an Senior Research Scientist who can work on different aspects of the video content, like text...
$85k - $135k
Senior Chemist 3 3 Locations Available | req2118 Job available in these locations: Seattle, WA, United States Vancouver, WA, United... ...DUTIES/RESPONSIBILITIES In this position, you will: Serve as scientist/chemist to perform project support and provide chemistry...Full timeWork experience placementRelocation package$84k - $100k
...Committee for Children is an amazing place to grow your career as a Research Scientist. We're a social enterprise dedicated to advancing the well-... ...non-technical audiences. Here's what we're looking for: ~3+ years of experience conducting program evaluation involving...Work at officeRemote workFlexible hoursCommittee for Children
Medina, WA4 days ago- ...human workforce could achieve. With over $404M in funding, a $3.5B valuation, and partnerships with leading health systems, we... .... At the center of that platform is voice. As a Senior Staff Research Scientist in Speech Technologies, you'll lead the research and engineering...Work at officeRemote work
AI Chopping Block, Inc.
Bellevue, WA3 days ago - ...Employer: AMAZON DEVELOPMENT CENTER U.S., INC. Offered Position: Research Scientist III Job Location: Seattle, Washington Job Number: AMZ100... ...including generative models for business applications, and (3) programming in Java, C++, Python or related language....Work at office
Amazon
Seattle, WA2 days ago - ...Machine Learning Scientist Sesame believes in a future where computers are lifelike - with... ...Learning Scientist at Sesame, you are a research-oriented person with experience in NLP, Speech... ...: ~401 (k) max employer match: 3.5% of compensation ~100% employer-paid...Full timeContract workFlexible hours
SESAME
Bellevue, WA3 days ago $192k - $304.75k
We are now looking for a Senior Robotics Research Scientist! NVIDIA is at the forefront of the AI and robotics revolution, and our robotics teams... ...is aiming to achieve never-before-seen capabilities within 2-3 years. We are looking for world-class senior research...Full timeWork at office$159.2k - $215.3k
...and we’re innovating for them. As a survey scientist you will you will design and carry out... ...will conduct methodological and statistical research to understand the quality of survey data.... ...manage and execute)Basic qualifications- 3+ years of investigating the feasibility...Flexible hours$136k - $184k
...become your best.Basic qualifications- PhD, or Master's degree- 3+ years of industry work experiencePreferred qualification - Ability... ...are commonly used in modern data analysis.- Work with a team of researchers to extend and interpret advanced analytical methodologies.Amazon...Local areaFlexible hours$159.75k - $255.6k
...matter.Your ImpactWe are seeking a skilled and innovative Senior Research Scientist to join one of our AI teams focusing on computer vision and... ...community.Coach and mentor junior scientists.What You BringPhD and 3+ years experience in Computer Science or a related field with...Work experience placementWork at officeRemote work- ...recommendation lists, enabling end-to-end modeling based on large models.3. Item Tokenization for Recommendation:Efficiently encoding... ...for generative recommendation systems- Contribute to the research community via internal papers, patents, or external publications-...
- ...experience for our TikTok users.Responsibilities:• Conduct cutting-edge research in machine learning algorithms, such as retrieval and... ...related technical field or equivalent industrial research experience.• 3+ years of working experience in one of the following fields:...Temporary workWork experience placement
- ...intelligent agents.We value original exploration and encourage both research thinking and engineering excellence. Every team member is... ...integrating multimodal understanding and generative capabilities.3. Apply LLM technologies across retrieval, ranking, and re-ranking...
- Intelligent Creation team focuses on conducting cutting-edge research and development in the area of Computer Vision, Computer Graphics, and... ...intelligence technology at its core.Minimum Qualifications1. 3+ years of research and practical experience in one or more areas...
$125.5k - $169.8k
We’re looking for a Research Scientist to join a team that measures and explains how over 2.4 million sellers and vendors experience selling on... ...qualifications- PhD in a quantitative field, or MS degree and 3+ years of quantitative field research experience- Experience...Remote workFlexible hoursShift workDay shift- FHLB Des Moines is seeking a Research Scientist/Engineer 3 for their Cancer Vaccine Institute team located in Seattle. This role involves executing laboratory operations for clinical trials aimed at developing new cancer therapies. Applicants must have a Bachelor's degree...Full time
$184.7k - $200.2k
Research Scientist at Meta - Bellevue, WA Meta Platforms, Inc. (Meta), formerly known as Facebook Inc., builds technologies that help people connect... ...2. Solving analytical problems using quantitative approaches 3. Gathering, manipulating, or analyzing complex, high‑volume,...Hourly payInternshipLive in- The Northwest Genomics Center at the University of Washington is seeking a Research Scientist 3, Genomics to lead high-throughput sequencing projects. You will perform DNA and RNA library construction, apply methylation analysis, and ensure data quality across large cohorts...
$285k - $380k
...People Research Scientist, Recruiting San Francisco, CA | New York City, NY | Seattle, WA About Anthropic Anthropic's mission is to create... ...our team worked on prior to Anthropic, including: GPT-3, Circuit-Based Interpretability, Multimodal Neurons, Scaling...Work at officeVisa sponsorshipFlexible hoursAnthropic
Seattle, WA1 day ago$3,118 per week
...Technologist Job are: Specialty: Cath Lab Technologist Job Location: Seattle, Washington Travel Allied Health Salary: $3,118/week Start Date: 09/07/2026 Assignment Length: 17 weeks Total Hours Per Week: 40 weekly Shift Breakdown: 4...Daily paidLong term contractTemporary workLocal areaFlexible hoursShift workHealth Advocates Network - Allied
Seattle, WA4 days ago$137.75k - $237.5k
Machine Learning Research Scientist Graduate (Atomistic AI) - 2026 Start (PhD) Join to apply for the Machine Learning Research Scientist Graduate... ...Equity (*11-Month LTE) Seattle, WA $186,400.00 - $314,900.00 3 weeks ago Seattle, WA $177,000.00 - $251,000.00 1 week ago...Full timeTemporary workInternshipLocal areaRemote work$167.1k - $226.1k
...partnerships. We are seeking a Sr. Applied Scientist to join our Communities team. The... ...risks, and constructively critique peer research - Consult with engineering teams to design... ...validation. BASIC QUALIFICATIONS - 3+ years of building machine learning models...Flexible hours- ...inference platform. Description Location: Seattle, WA (Hybrid - 3 days/week in office) About ElastixAI: ElastixAI is an early-... ...Role Summary: We are looking for a talented Machine Learning Research Scientist to play a key role in designing our core AI inference platform...Work at officeFlexible hours3 days per week
$202.16k - $368.22k
Senior Research Scientist - DPU & AI Infra Location: Seattle Team: Infrastructure Employment Type: Regular Job Code: A17626A Team Overview... ...related fields; or Ph.D. with strong research/publications. 3+ years of relevant industry experience (exception for Ph.D. with...Temporary workLocal area
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Research Scientist/Engr 3. Be the first to apply!
Related searches
- scientist ii Seattle, WA
- scientist 1 Seattle, WA
- image scientist Seattle, WA
- downstream processing scientist Seattle, WA
- qc scientist Seattle, WA
- research scientist Seattle, WA
- analytical scientist Seattle, WA
- research scientist - biology Seattle, WA
- genomics scientist Seattle, WA
- quality control scientist Seattle, WA