Principal Scientist - RGM Chemistry

We are looking for a visionary Principal Scientist – RGM Chemistry to lead the discovery, development, and optimization of antibody-oligonucleotide conjugation technologies that power next-generation targeted therapeutics. Sitting at the intersection of bioconjugation chemistry, RNA science, and process innovation, you will set scientific strategy, guide a multidisciplinary team, and translate ground breaking concepts into scalable solutions that advance our therapeutic pipeline. Your deep expertise, collaborative attitude, and passion for mentoring will drive breakthrough medicines from bench to preclinical validation and beyond.

Typical Day

• Designing and completing experiments to refine linker chemistry, payload stability, and delivery efficiency for antibody-oligo conjugates
• Analyzing conjugates with HPLC, LC-MS, and bioassays to ensure purity, identity, and functional potency
• Leading project stand‑ups, mentoring scientists and research associates, and troubleshooting technical challenges in real time
• Partnering with Process Development and Manufacturing to scale promising conjugation methods for preclinical supply
• Scouting and evaluating emerging bioconjugation or RNA delivery technologies and proposing data‑driven innovation projects
• Presenting program updates and strategic recommendations to senior R&D leadership and cross‑functional partners

This Job Might Be For You

• Thrive on pushing the boundaries of antibody and oligonucleotide conjugation science
• Enjoy mentoring and developing talent in a collaborative, fast‑paced research environment
• Translate sophisticated data into clear, actionable insights and strategic plans
• Demonstrate a strong record of innovation, publications, and/or patents in bioconjugation or RNA therapeutics
• Excel at balancing deep scientific rigor with pragmatic process development and scale‑up considerations
• Are motivated by cross‑functional collaboration that accelerates breakthrough medicines to the clinic

Qualifications

• A Ph.D. in Chemistry, Biochemistry, Molecular Biology, or related field with 5+ years of postdoctoral or industry experience in antibody/oligonucleotide conjugation
• Validated expertise in bioconjugation, oligonucleotide therapeutics, and advanced analytical techniques (HPLC, LC-MS, bioassays)
• Proven leadership of multidisciplinary teams and successful track record in advancing therapeutic candidates toward preclinical or clinical development

Benefits

• Health and wellness programs (medical, dental, vision, life, disability)
• Fitness center access
• 401(k) with company match
• Family support benefits and equity awards
• Annual bonuses and paid time off, including military and parental leave
• Other benefits vary by location

Equal Opportunity Employment

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company’s business.

Salary Range

$128,600.00 – $210,000.00 per year.