Lead Systems Engineer

Building the technology biopharma actually needs.

At MantaBio, we're building technology that helps biopharma manufacturers detect microbial contamination in real time — dramatically reducing risk and accelerating timelines for the therapies that depend on it.

Our mission is to replace outdated, slow cell-culture testing with fast, accurate, and automated solutions that meet the needs of modern biologics production. Everyone here plays a hands-on role in shaping the product, the company, and the culture.

If you're energized by building from the ground up — and want your work to matter — we'd love to meet you.

Why work with us.

We're not just building a product — we're solving a real problem in an industry that needs better tools. Your work has clear purpose and immediate impact.

• Meaningful equity ownership — be part of the upside
• Full medical, dental, and vision benefits
• Unlimited PTO — we trust you to take the time you need
• Exposure to cutting-edge science and automation
• Direct access to leadership and rapid career growth

Beverly, MA

About the Role

As Lead Systems Engineer, you'll be instrumental in integrating mechanical, electrical, fluidic, optical, and consumable components into a cohesive platform. You'll help drive development of a complex, fully integrated product — transitioning from prototype to commercial readiness. This role requires deep technical fluency, cross-disciplinary thinking, and a hands‑on approach.

What You'll Do — Systems Integration & Prototyping

• Design and build electromechanical subsystems including fluid handling, thermal cycling, and optical detection.
• Develop breadboards and alpha prototypes to mitigate technical risk prior to commercial development.
• Integrate pumps, valves, manifolds, heaters, sensors, and optics into reliable systems.

Design & Development

• Use CAD (SolidWorks preferred) for mechanical design and support prototyping via CNC machining, 3D printing, or injection molding.
• Analyze experimental data to inform iterative design (bonus points for Python or MATLAB fluency).

Cross-Functional Collaboration

• Partner with software, biology, chemistry, and electronics teams to ensure seamless integration.
• Operate with autonomy and a "get it done fast" mindset in a startup environment.

What You Bring

• 10+ years of experience as a systems engineer in hardware-focused environments.
• MS in Engineering preferred but not required.
• Proficiency in CAD and one or more data analysis environments (Python, MATLAB, etc.).
• Hands‑on, self‑directed, and execution‑driven mindset.

What We Offer

• Salary: Competitive within early‑stage startups
• Benefits: Health, dental, vision, and 401(k)