Senior Director, Clinical Development

Company OverviewTango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.Summary The Senior Director, Clinical Development will provide medical and scientific leadership for Tango’s oncology development programs, driving clinical strategy from early-stage development through registration. Reporting to the President, Research & Development, this individual will lead cross-functional clinical teams, shape development plans, oversee study execution and medical monitoring, and serve as a key partner to investigators, regulators, and senior leadership. This highly visible role combines strategic leadership with hands-on clinical development responsibilities and offers the opportunity to directly influence the advancement of innovative precision oncology therapies for patients. The Senior Director will build and maintain strong relationships with investigators, key opinion leaders (KOLs), and external partners while ensuring the successful execution of clinical studies and overall program objectives. Your Role: Lead the clinical development strategy and execution for assigned clinical-stage oncology asset(s), partnering with cross-functional teams to create and implement comprehensive clinical development plansProvide leadership to the clinical team and serve as the medical and scientific expert for development programsDesign, author, and oversee the development of study protocols, protocol amendments, investigator brochures, and other key clinical documents in compliance with project plans, global regulations, ICH/GCP guidelines, and Good Medical PracticeServe as the primary clinical lead for study investigators and key opinion leaders, building strong relationships that support program success and scientific advancementLead clinical contributions to regulatory submissions, including INDs, CTAs, NDA/MAA filings, and interactions with Health AuthoritiesAct as Medical Monitor and/or oversee external Medical Monitors for company-sponsored clinical trials, ensuring appropriate medical oversight and patient safetyProvide strategic oversight of adverse event review, safety monitoring, protocol compliance, and clinical data evaluationPartner closely with Clinical Operations, Clinical Pharmacology, Biometrics, Regulatory Affairs, Drug Safety, Data Management, Quality, and Translational Sciences to ensure integrated and efficient execution of development programsAnalyze and interpret clinical trial data and communicate findings through regulatory submissions, scientific publications, medical congress presentations, and internal governance reviewsLead responses to questions from Health Authorities, Ethics Committees, and Institutional Review Boards, ensuring consistency and scientific rigorContribute to portfolio strategy, development planning, and broader organizational initiatives as neededPerform additional responsibilities as required to support the advancement of Tango’s clinical programsWhat You Bring: MD required; board certification or board eligibility in Medical Oncology, Hematology/Oncology, or a related specialty strongly preferred5+ years of clinical development experience within the biotechnology and/or pharmaceutical industry, including experience leading oncology development programsDemonstrated experience in the design, execution, interpretation, and reporting of oncology clinical trials involving targeted therapies, small molecules, and/or immuno-oncology agentsExperience supporting or leading late-stage clinical development programs, NDA/BLA/MAA submissions, and Health Authority interactionsStrong understanding of the biological and translational sciences underlying modern oncology drug development, including molecular biology, cancer genetics, immunology, and precision medicine approachesProven ability to lead and influence cross-functional teams within a matrixed organizationExcellent strategic thinking, organizational, and project leadership skills, with the ability to balance high-level planning and hands-on executionStrong problem-solving skills and the ability to identify innovative approaches to advance development programs and organizational objectivesExceptional communication and presentation skills, including the ability to engage effectively with senior leadership, investigators, KOLs, and regulatory agenciesDemonstrated leadership capabilities with a collaborative, team-oriented, and results-driven approachFlexible, resourceful, and entrepreneurial mindset with the ability to thrive in a dynamic and fast-paced biotechnology environment  #LI-HybridWe are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.Salary range $274,400—$411,600 USD