Physician Scientist Obesity and Liver Disease Human Genetics

Physician Scientist Opportunity

We are looking for an exceptional Physician Scientist to join our Cardiometabolic Therapeutic Area Genetics (TAG) team at the Regeneron Genetics Center (RGC). Within the RGC, the Cardiometabolic TAG team is using massive scale human exome sequencing for discovery and validation of new therapeutic targets in obesity and obesity associated metabolic disease. The position holder will collaborate with various RGC teams and with pre-clinical and clinical development teams at Regeneron to accelerate therapeutic development for genetically-validated targets in obesity and metabolic disease via the generation of new human genetics and epidemiological insights.

In this role, a typical day might include the following:

• Accelerate therapeutic development for genetically-validated targets via the generation of new human genetics and epidemiological insights.
• Generate key research questions and then design and execute studies and analyses to help address these questions, interpret the results of these studies and summarize ensuing insights in a variety of formats for different audiences (e.g. documents, presentations, patent applications, publications, etc.).
• Understand and leverage RGC and Regeneron datasets, external resources and the scientific/medical literature to address key research questions at hand and summarize results giving appropriate weight to quantitative and qualitative strength of evidence.
• Support target nominations and validation utilizing the RGC's human genetics capabilities and leveraging Regeneron's extensive internal therapeutics platforms and development modalities.
• Partner with Clinical Development to evaluate clinical stage programs and opportunities for human genetics studies to aid in the selection of indications or evaluation of safety considerations.
• Participate in the intellectual life of the Cardiometabolic TAG, the RGC and Regeneron at large and help build an inclusive work culture where everyone can perform at their best and fully develop their talent and potential.
• Represent the Therapeutic Area Genetics team in cross-functional initiatives within RGC and Regeneron.

This job might be for you if you have:

• Demonstrated ability to design and lead human genetics and epidemiological studies delivering medically-relevant findings in a team-based environment.
• Ability to use medical knowledge to define relevant phenotypes for genetic association studies and to formulate innovative and important research questions. Familiarity with clinical genetics concepts and various genetic models of disease.
• Strong computational and quantitative skills including ability to design and execute complex analyses using large scale datasets both with individual-level as well as result-level data (e.g. UK Biobank, All of US, MVP, Biobank Japan, meta-analysis of genome-wide summary statistics, etc). This includes proficiency with R or similar software and familiarity with high performance computing environments.
• Experience leading complex human genetics research endeavors. Knowledge of different study designs and analyses including GWAS, exome or genome sequencing in cohort, case-control or family-based studies. Ability to integrate different data resources to translate initial findings.
• Familiarity with the applications of genetics to gain medically-actionable insights including polygenic risk scores, quantitative traits analyses and Mendelian randomization.
• Understanding of drug development and clinical trial design and execution. Experience as investigator in Randomized Controlled Trials is a plus. Experience in the clinical management or medical research relating to cardio-metabolic disease is not strictly required but is a plus.

To be considered for this role, you must have a MD with strong background in and knowledge of human genetics and genetic epidemiology. An outstanding candidate will be an MD/PhD with training and experience in translational human genetics, genetic epidemiology, epidemiology (or related disciplines) and strong quantitative skills.