VP, US Site Management & Operations - GI

Iterative Health is a healthcare technology and services company powering the acceleration of clinical research to transform patient outcomes.

We built a leading performance-driven network of 100+ sites across the US, Europe, India, and Australia, conducting research directly in the communities where care is delivered across gastrointestinal, hepatology, obesity, and cardiology. By combining deep clinical trial expertise with cutting-edge AI, we connect sponsors' scientific ambitions with high-performing research teams that expedite and expand access to novel therapeutics for patients in need. Today, Iterative Health is headquartered in Cambridge, Massachusetts, and New York City with 250+ employees world-wide.

As the VP, US Site Management & Operations at Iterative Health, you will lead the performance, growth, and operational excellence of our GI and Hepatology network of clinical research sites across the United States.

You’ll be accountable for the performance and P&L of 50+ US-based sites, driving research revenue as a meaningful growth engine and building the operational excellence that makes our sites the best place to run a clinical trial. You’ll set the strategy and operating model to scale the network while delivering exceptional experiences for patients, Principal Investigators, sponsors, and study teams.

This is a hands-on executive leadership role with direct accountability for results. You’ll lead a team of Regional Directors who oversee Site Managers, Clinical Research Coordinators, Research Assistants, and other research professionals, while partnering closely with Principal Investigators and leaders across the organization to drive performance, growth, and scale.

Where You’ll Drive Impact

Site Performance & Management

• Own site health, revenue, P&L, and operational performance across Iterative Health’s US GI site network.
• Establish clear reporting, performance benchmarks, and action plans to drive continuous improvement and sustainable growth of our sites.
• Proactively identify performance gaps and partner across functions to address barriers to revenue, productivity, capacity, and study execution.
• Own staffing strategy across the network, partnering with the People Team to ensure sites are appropriately staffed and positioned for growth.
• Oversee day-to-day site operations, capacity, and study portfolio management, ensuring the right studies are matched to the right sites and that sites are positioned to maximize enrollment and research revenue.
• Identify opportunities to expand site capabilities, capacity, and research volume across the GI and Hepatology network.
• Drive enrollment, data quality, compliance, and overall study execution against premium network benchmarks.
• Ensure teams are aligned, appropriately resourced, and accountable for delivering study and network commitments and operational targets.
• Own the site operations workstream for M&A integrations, partnering with cross-functional leaders to assess operational readiness, integrate acquired sites and teams, align processes and systems, and ensure a seamless transition into the Iterative Health operating model.
• Partner closely with Site Solutions, Study Success, Life Sciences, Finance, People, Product,, and other key stakeholders to align site strategy, resources, and execution with broader company objectives.

Deep Site Relationships & People Management

• Build deep relationships with key Principal Investigators and establish a consistent standard for PI engagement across the network..
• Build relationships with the broader practice, including practice leadership to drive engagement and buy-in to research
• Build a culture of ownership, accountability, development, and retention through strong leadership, training, and career development for site level staff
• Additional responsibilities as needed to support the company’s strategic priorities.

What You Bring to the Team

• 12+ years of progressive leadership experience in healthcare, clinical research, healthcare services or related field in a multi-site organization.
• Bachelor’s degree required; advanced degree in healthcare, business, life sciences, or a related field preferred.
• Proven experience building, scaling, or transforming a healthcare service line, business unit, or multi-site operation in a high-growth environment.
• Demonstrated ownership of P&L, revenue growth, operational performance, and resource allocation.
• Experience participating in M&A, acquisitions, integrations, or organizational transformation strongly preferred.
• Strong understanding of clinical research and/or healthcare operations, with GI experience a plus.
• Proven ability to translate strategy into execution and drive measurable results across distributed organizations.
• Exceptional people leadership skills, with experience building teams, developing leaders, and fostering accountability and high performance.
• Strong track record of building trusted relationships with clinicians and senior stakeholders and driving alignment across diverse groups.
• Demonstrated success partnering cross-functionally across Operations, Finance, Commercial/Business Development, and People to build and scale a business.
• Entrepreneurial, hands-on leadership style with the ability to operate strategically while staying close to execution in a high-growth environment.

How We Work

• Collaborative and low-ego team environment
• High ownership and accountability culture
• Fast-paced and highly iterative growth environment
• Open communication and continuous learning mindset
• Mission-driven organization focused on improving patient outcomes
• Comfortable navigating evolving business priorities and opportunities

Benefits That Support You

We believe great teams do their best work when they feel supported — professionally and personally.

• Hybrid work environment with in-office collaboration two days per week in either our NYC, Boston or Southlake office
• Comprehensive medical, dental, and vision coverage, with up to 80% of premiums covered by Iterative Health
• Mental health and wellness support through Spring Health
• Health HSA or FSA options, and commuter FSA contributions supported by Iterative Health
• Unlimited PTO, 12 company holidays, and a company-wide shutdown between Christmas and New Years
• 401(k) program with a company match of up to 3% (up to $3,000 annually)
• Weekly in-office lunch benefit every Tuesday
• 100% company-paid short-term and long-term disability coverage
• Annual wellness and professional development stipend to support your health and growth

At Iterative Health, we’re actively working towards creating an environment that is representative of the diversity of patients our technology serves. We are focused on building an equitable and inclusive culture, and by extension, hiring process. If you require any accommodations to make the application process or interviewing experience more accessible to you, please contact View email address on click.appcast.io.