Scientist, Oligonucleotide Synthesis

Position Summary The successful candidate will help to establish pre‑clinical capabilities within GSK's growing oligonucleotide synthesis lab. Areas of focus include SPOS of modalities such as ASOs, siRNA, SSO, and RNA editors screening, high‑throughput automation, conjugates and method development. Your expertise will enable us to solve complex chemical challenges, pushing the boundaries of oligonucleotide therapeutics. Responsibilities Support pre‑clinical oligonucleotide high‑throughput and mid‑scale synthesis capabilities of ASOs, siRNA, SSO, and RNA editors with routine and novel next‑generation amidite chemistries. Perform hands‑on work and maintain high‑throughput automation workflows in support of routine and next‑generation chemistry and oligo method development. Maintain standard operating procedures (SOPs) for synthesis, processing, and purification to ensure high‑quality, reproducible results. Work with the oligo analytical and delivery chemistry teams to ensure accountability and excellence in oligonucleotide and conjugate synthesis. Collaborate with various teams to achieve synthetic project goals. Basic Qualifications MS with 2+ or BS with 4+ years of experience in chemistry, chemical biology, or a related field. Direct experience with laboratory automation platforms such as the Lynx from Dynamic Devices, the Fluent from Tecan, or similar platforms. Familiarity with Mermade 192X, Dr. Oligo 192 XLc, or other high‑throughput synthesizers, LC/HRMS, UPHLC, LC/MS analytics. Proficiency in oligonucleotide synthesis (SPOS) and biological understanding of RNA therapeutics (e.g., ASO, siRNA, SSO, RNA editors). Preferred Qualifications MS with 2+ years or above in oligonucleotide synthesis and/or chemistry and/or related field. Team‑focused with strong initiative and ability to troubleshoot challenges and implement new solutions. Excellent written and verbal communication skills, attention to detail, organizational skills, and ability to collaborate effectively with a team. Experience with oligonucleotide conjugation chemistries is desirable but not required. Sense of urgency, flexibility, independence and accountability. Ability to communicate both verbally and in writing with all levels inside and outside the organization. Maintain a high level of integrity while balancing multiple priorities and responsibilities. Committed team player prepared to work in and embrace a team‑based culture. Working Arrangement This is an on‑site role based at GSK's Cambridge, MA laboratory location. Hybrid or remote arrangements are not available for this position. Compensation & Benefits Annual base salary ranges from $96,525 to $160,875 depending on location. Annual bonus and eligibility to participate in a share‑based long‑term incentive program. Benefits include health care and other insurance benefits, retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. EEO Statement GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law. #J-18808-Ljbffr GlaxoSmithKline