Executive Director, Modeling & Simulations

Executive Director, Modeling & Simulations The Executive Director, Modeling & Simulations (M&S) manages strategic, scientific and operational aspects of M&S within the Early Clinical Development Department at Vertex. The incumbent is responsible for the implementation of modeling and simulation strategy at Vertex; including but not limited to traditional PK/PD, population PK, exposure‑response, model‑based meta‑analysis, clinical trial design and simulation, mathematical disease models, mechanistic modeling and analyses of multidimensional data. This role will have final approval on providing direction and guidance for M&S plans across programs. Key Duties and Responsibilities Leading and developing the Modeling & Simulation team Champion the use of modeling and simulation to impact decision making in clinical and exploratory development Manage a group of senior leaders comprised of Senior Directors and Director level employees Provide expert input for internal review of all documents internal and external related to modeling and simulation or M&S derived outputs Represent programs in external partnerships and advisory boards Oversee and contribute to regulatory and safety documents Represent modeling and simulation during face‑to‑face regulatory interactions Provide management and career development to associate program leads Assist in recruitment and hiring for the M&S group Knowledge and Skills Demonstrated ability to lead teams and manage people Experience designing clinical pharmacology and pharmacometrics components of filing packages and associated clinical studies Regulatory agency interactions including written responses and IND packages End of Phase 2 and NDA/MAA regulatory experience Support of drug development programs in all Phases including life‑cycle management Strong experience leading cross‑functional teams Academic or clinical post‑doctoral training with significant publication history Superior communication skills Proactive problem solver and demonstrated ability to work in a matrix environment Education and Experience Master's or PhD in Pharmaceutical sciences, Pharmacometrics, mathematics, statistics, or other quantitative discipline with an emphasis on Pharmacometrics and PK/PD modeling Requires PhD with 20 years or Master's with 25 years’ experience in the application of pharmacometric and other modeling methodologies in drug research & development in industry, academia or regulatory agencies Strong management experience Pay Range $268,000 - $402,000 Disclosure Statement The range provided is based on a reasonable estimate for the base salary pay range for the position at the time of posting. The role is eligible for an annual bonus and annual equity awards, and may also be eligible for overtime pay in accordance with federal and state requirements. Equal Employment Opportunity Vertex is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E‑Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. #J-18808-Ljbffr Vertex Pharmaceuticals