Principal Scientist II - Pharmacology

Job Description Summary NIBR Oncology strives to reimagine medicines for cancer patients through a combination of treatment approaches including targeted therapies, immunotherapies, CAR‑T, and radioligand therapy. We are seeking an in‑vivo scientist to join our Oncology Pharmacology team in Cambridge, MA. The successful candidate will lead design and execution of in‑vivo anti‑tumor efficacy and PK/PD studies, develop novel in‑vivo assays, and deliver translationally relevant data to inform clinical development. Location: Cambridge, MA. This position is onsite only; remote work is not possible. Please only apply if you can work in this area. Responsibilities Design pre‑clinical in‑vivo studies to explore novel hypotheses, screen candidate molecules, and establish proof‑of‑concept of new modalities Develop in‑vivo CDX, PDX, and syngeneic models to evaluate anti‑tumor activity, PK/PD relationships, relevant biomarkers, and key translational questions Manage associate‑level scientists Collaborate with cross‑functional project teams Critically analyze and present results within a multidisciplinary team environment Ensure careful adherence to animal protocols and proper documentation of data and methods in an electronic laboratory notebook Qualifications PhD with 5‑8 years of research experience as a postdoctoral fellow or in the pharmaceutical/biotech industry Deep knowledge of antibody drug conjugates Extensive experience working with CDX and PDX xenograft tumor models and/or syngeneic models Expertise in cell culture, PCR, ELISA, western blot, and flow cytometry Strong analytical, written and verbal communication, and organizational skills; proficiency with PowerPoint and commonly used data analysis programs such as Prism and Excel Compensation & Benefits The salary for this position is expected to range between $126,000 and $234,000 per year. Compensation includes a performance‑based cash incentive and, depending on the level of the role, eligibility for annual equity awards. US‑based eligible employees receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. Employees are also eligible for a generous time‑off package including vacation, personal days, holidays, and other leaves. Salary Range $126,000.00 – $234,000.00 Skills Desired Analytical Skill, Analytical Thinking, Chemical Biology, Chemistry, Clinical Trials, Collaboration, Communication Skills, Curious Mindset, Data, Data Analysis, Design Of Experiments, Detail‑Oriented, Drug Development, Drug Discovery, Ethics, Gene Therapy, Immunology, Inventory Management, Laboratory, Lifesciences, Machine Learning (ML), Management, Medical Research, Molecular Biology {+ 10 more} EEO Statement The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. Accessibility and Reasonable Accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e‑mail to View email address on click.appcast.io or call View phone number on click.appcast.io and let us know the nature of your request and your contact information. Please include the job requisition number in your message. #J-18808-Ljbffr Healthcare Businesswomen’s Association