Vice President, Medical Affairs Oncology

Vice President, Medical Affairs OncologyCambridgeParabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines for patients with serious diseases by unlocking biologically important targets long considered undruggable. The company has pioneered a new class of alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that have historically been beyond the reach of conventional medicines. The company's lead investigational medicine, zolucatetide, is the first and only direct inhibitor of the ?-catenin:TCF interaction, a central node in the Wnt/?-catenin pathway that has eluded drug developers for decades. Zolucatetide is being evaluated in the clinic across multiple Wnt/?-catenin-driven diseases, including desmoid tumors, familial adenomatous polyposis (FAP) and a range of other solid tumor indications. Beyond zolucatetide, Parabilis is advancing additional Helicon-based programs focused on other challenging targets where we believe our medicines could have life-altering impact.The Vice President, Medical Affairs Oncology is a member of the Development Leadership Team reporting to the Chief Medical Officer. This senior executive leader is accountable for the end-to-end design and execution of the Medical Affairs strategy across Parabilis portfolio, including Scientific Communications, Medical Education, Evidence Generation, Key Opinion Leader (KOL) Engagement, Publication Planning, and Medical Information. This role ensures scientific excellence and cross-functional integration across all development programs and builds a scalable Medical Affairs organization capable of supporting global, multi-indication growth.Key Responsibilities:Define and execute the Medical Affairs Oncology strategy aligned with the clinical development roadmap and portfolio prioritiesServe as a core member of the Development Leadership Team and contribute to broader development governance and portfolio decision-makingSupport portfolio-level medical prioritization, lifecycle planning, and cross-indication strategyBuild and sustain relationships with leading KOLs, academic medical centers, and cooperative groups relevant to Parabilis' pipelineDesign and oversee Medical Education programs that advance understanding of Parabilis' science, novel mechanisms, and unmet need across tumor typesLead the development and execution of a robust evidence generation strategy, including investigator-initiated studies, real-world evidence, and health outcomes researchOversee development and execution of a comprehensive publication plan aligned with clinical milestones and regulatory timelinesBuild global medical affairs infrastructure to support multi-program, multi-regional growthDrive medical affairs KPIs and impact metrics in support of portfolio strategy and commercial readinessLead scientific communications strategy to accurately and compellingly convey the differentiated profile of Parabilis' Helicon™ platform and pipeline assetsOversee Medical Information function, ensuring timely, accurate, and compliant responses to healthcare professional inquiriesOversee the creation of high-quality medical education materials, slide decks, and scientific exchange resourcesEstablish scalable medical affairs infrastructure to support launch readiness across tumor types and geographiesBuilding trusted partnerships with advocacy organizations across Parabilis' specific tumor typesIntegrating the patient voice into MA strategy, trial design, and evidence generationCollaborating with patient communities on disease awareness and educationDeveloping patient support programs to improve access, adherence, and trial participation ensuring all patients' engagement is conducted with ethical rigor and full compliancePartner closely with Clinical Development, Regulatory Affairs, and New Product Planning to ensure scientific and medical alignment across the development and pre-commercialization continuumSupport payer strategies by contributing to value dossiers, HEOR data packagesLead development and continuous improvement of Medical Affairs SOPs, governance frameworks, and compliance systemsEnsure all Medical Affairs activities are executed in accordance with applicable regulations, industry codes, and Parabilis' internal policiesBuild and mentor a high-performing Medical Affairs Oncology team with deep scientific expertise and strong cross-functional collaboration skillsEstablish clear accountability, performance metrics, and a culture of scientific rigor and integrityFoster a culture of collaboration, scientific curiosity, and patient-centricity across the Medical Affairs teamWhat you'll need to be successful:MD required; PharmD or PhD in a relevant biomedical discipline may be considered with commensurate experience15+ years of progressive biopharmaceutical industry experience, with a minimum of 8 years in Medical Affairs with deep scientific expertise in oncologyDemonstrated success building and leading Medical Affairs organizations, including KOL engagement, evidence generation, and scientific communicationsExperience standing up Medical Affairs capabilities in high-growth, clinical-stage biotech or pharmaceutical environmentsStrong scientific credibility, executive leadership presence, and ability to engage effectively with both internal and external stakeholdersHigh emotional intelligence and track record of cross-functional influence across Development, Commercial, and Regulatory functionsCore Values:Growth-Minded . We're inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.In(ter)dependent. We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.All-In. We're All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.The base salary range for this position is $360,000-$410,000 per year, depending on experience, qualifications, and internal practices. Parabilis's total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees' overall well-being.As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.