Principal Scientist/ Senior Principal Scientist, Large Molecule Biology

Principal Scientist / Senior Principal Scientist At Lilly, we serve an extraordinary purpose: we make a difference for people around the globe by discovering, developing, and delivering medicines that help them live longer, healthier, more active lives. Beyond breakthrough medicines, we support communities through philanthropy and volunteerism. As a member of Oncology – Large Molecule Biology, you will join a team at the forefront of pharmaceutical science, designing and executing studies that advance portfolio programs with minimal supervision. You will apply deep expertise in biological assays, develop and optimize specialized methods, and collaborate cross-functionally to support multiple research programs. In this role, you will design and execute in vitro and ex vivo studies that advance priority oncology targets through the drug discovery pipeline. Working with minimal supervision, you will contribute to multiple programs, develop new methods, and partner across disciplines to inform decisions on therapeutic candidates. Execute in vitro pharmacology assays to evaluate tumor cell signaling, antibody binding and internalization, cytotoxicity, effector function, cytokine release, and other cellular responses for medium- and high-throughput drug screening. Develop, validate, and run bioanalytical assays and maintain, culture, and passage multiple cell lines to support experimental objectives. Conduct multiparameter flow cytometry and other in vitro and ex vivo assays (e.g., receptor occupancy, receptor density, PK/PD, tumor isolation, and blood cell analysis) to characterize binding interactions and cellular responses. Oversee experimental work conducted by third-party collaborators and vendors, and partner with project and senior leaders to advance molecules through development. Present findings to technical and non-technical stakeholders through preclinical reports, team meetings, and presentations. Basic Requirements: B.S. in Biology, Chemistry, Pharmacology or a related field with 5+ years of relevant experience, or an M.S. in Biology, Chemistry, Pharmacology or a related field with 3+ years of relevant experience (role level based on relevant experience). Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role. Additional Skills/Preferences: Demonstrated expertise in mammalian cell culture techniques. Extensive hands-on experience performing in vitro and ex vivo assays. Strong understanding of in vitro pharmacology and related data analysis. Ability to design and execute comprehensive experimental plans on schedule. Demonstrated ability to collaborate across scientific disciplines to achieve business objectives. Demonstrated excellence in written and verbal communication and interpersonal skills. Previous experience with biologic modalities such as monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), and CD3-engaging platforms. Proficient in multiparameter flow cytometry, including panel design and data analysis. Prior work developing and validating bioanalytical assays. Proven ability to independently lead and advance multiple research programs with minimal supervision. Track record of managing external collaborations and CRO/vendor relationships. Strong record of presenting scientific findings to both technical and non-technical audiences. Knowledge of, and strong interest in, cancer disease states (indications, mutational status, tumor cell drivers, etc.). Additional Information: Location: New York, NY. Travel: less than 10% expected. Physical demands are consistent with a laboratory bench setting and are required to perform the essential functions of this role. Work environment: this role is based in a research laboratory and reflects the conditions typically encountered while performing the essential functions of the position. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form for further assistance. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $71,250 - $187,000. Eli Lilly