Sr. Scientist, Electrochemical and Microarray DNA Synthesis

Sr. Scientist, Electrochemical and Microarray DNA Synthesis About this position Atlas Data Storage is pioneering the future of information technology by harnessing the unique properties of synthetic DNA for next-generation data storage solutions. We are seeking a highly skilled and motivated Sr. Scientist to join our R&D team focused on advancing our massively parallel, semiconductor-based DNA synthesis platform. This scientist will play a central role in developing and optimizing integrated electrochemical DNA synthesis workflows, contributing to both chemistry innovation and product development. The ideal candidate will bring deep technical expertise, hands‑on experience, and a collaborative spirit to help drive scientific and strategic goals in a fast‑paced, interdisciplinary environment. Essential Duties and Responsibilities Major contributor to the development and optimization of CMOS chip-based DNA synthesis workflows, including both phosphoramidite and enzymatic chemistries Develop and optimize electrochemical synthesis protocols, including chip handling, hardware configuration, and software integration, and process troubleshooting Investigate and refine surface functionalization strategies to improve synthesis efficiency and fidelity Collaborate with engineering and synthesis teams to build and iterate prototype testbeds, integrating chemistry, fluidics, and hardware systems Operate NGS-based analytical pipelines for quality assessment of oligonucleotide pools Analyze experimental data using molecular biology and organic chemistry techniques Drive technology transfer from R&D to manufacturing, ensuring robust scale‑up and process documentation Help define and execute scientific and technical objectives aligned with company goals Present experimental plans, results, conclusions, and next steps at group meetings, project team meetings, and company-wide meetings Maintain detailed and meticulous records of all experimental work and analysis Qualifications Advanced degree (PhD) in Chemistry, Organic Chemistry, Chemical Engineering, or a closely related field (or equivalent experience) Experienced MS or BS candidates with significant relevant experience also considered Experience in a biotech or pharma R&D environment is highly desirable Proven track record and proficiency in phosphoramidite oligonucleotide synthesis chemistry and platform development Experience in oligonucleotide microarray or pool synthesis is highly desirable Strong understanding of DNA chip technologies and synthetic biology applications Hands‑on experience with NGS workflows and data analysis is highly desirable Familiarity with software scripting for synthesis automation Demonstrated ability to participate in cross‑functional projects and collaborate across R&D and manufacturing teams Excellent problem‑solving, communication, and project management skills Physical Demands & Work Environment Work performed onsite in office and laboratory space located in South San Francisco Mobility: must be able to move about regularly; standing and walking for extended periods, often up to 6–8 hours per day Manual Dexterity: must have fine motor skills and steady hands to handle delicate instruments, operate lab equipment, pipette accurately, and perform repetitive benchwork with precision Lifting/Carrying: must be able to lift and carry up to 40 pounds occasionally Visual Acuity: sufficient visual acuity to read small print on labels, instrument displays, and computer monitors; close vision, color vision, and ability to adjust focus required Environmental Conditions: frequently exposed to typical laboratory conditions, including biological samples, chemicals, and reagents; must wear appropriate PPE such as lab coats, gloves, and safety goggles as required Pay Range 125,000 - 150,000 USD per year (HQ) #J-18808-Ljbffr Mammoth DS, Inc