Senior Manager, Solutions Architect

Senior Manager, Solutions Architect

Cambridge or Remote

Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines for patients with serious diseases by unlocking biologically important targets long considered undruggable. The company has pioneered a new class of alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that have historically been beyond the reach of conventional medicines. The company's lead investigational medicine, zolucatetide, is the first and only direct inhibitor of the β-catenin:TCF interaction, a central node in the Wnt/β-catenin pathway that has eluded drug developers for decades. Zolucatetide is being evaluated in the clinic across multiple Wnt/β-catenin-driven diseases, including desmoid tumors, familial adenomatous polyposis (FAP) and a range of other solid tumor indications. Beyond zolucatetide, Parabilis is advancing additional Helicon-based programs focused on other challenging targets where we believe our medicines could have life-altering impact.

Parabilis is scaling toward a commercial future, and the systems our teams rely on have too often grown one step at a time rather than being designed as coherent wholes. The Solutions Architect exists to change that. This is a senior, cross-functional design role that partners with business teams and internal technology functions to evaluate, design, and deploy streamlined, well-architected workflows and the data foundations beneath them. This role holds design authority for the systems and workflows it builds. It does not direct how any business team performs its work. Instead, it partners with those teams to translate how they need to work into cohesive, maintainable systems that let them add value rather than work around disconnected point solutions. You will be a force multiplier: the person who sees the whole board when everyone else sees their own square.

Owns (design authority): end-to-end architecture, workflow design, and data models for the systems you build. These are yours to decide, with the backing of the Sr. Director of IT.

Partners on: requirements with business stakeholders, and delivery with internal technology teams such as Cloud and Engineering. You coordinate and shape the work; you do not manage their people or their backlogs.

Operates within: the standards each function owns, including Cloud platform and infrastructure standards, Engineering scientific-computing and data-product standards, and IT security and compliance standards. You design inside those rails, not around them.

Key responsibilities:

• Partner with business teams to map current-state workflows, surface the root causes of friction, and design cohesive future-state systems rather than incremental patches.
• Own the architecture, workflow design, and data management approach for the systems you deliver, ensuring they interoperate cleanly with the broader technology estate.
• Translate business needs into clear system and data requirements and translate technical constraints back into terms stakeholders can act on.
• Coordinate delivery across internal technology teams (Cloud, Engineering) and external vendors, working within each team's standards while holding the coherence of the whole. Reduce reliance on disconnected, third-party-built point solutions by designing for the whole system and its interconnections, not one team in isolation.
• Establish design patterns, documentation, and data governance practices that make the systems you build maintainable and auditable over their life.
• Where systems touch GxP, clinical data integrity, or other regulated processes, design to meet applicable data integrity, validation, and compliance expectations in partnership with QA and IT compliance.
• Hand-off delivered systems to their long-term owners with the documentation and design rationale needed to operate and evolve them.

What you'll need to be successful:

Required

• 7+ years of demonstrated experience designing and deploying cross-functional business systems and workflows end to end, not just implementing point tools.
• Bachelor's degree in computer systems or related field a plus.
• Strong systems thinking and data-architecture skills: the ability to model how processes, systems, and data should fit together across teams.
• A track record of partnering with non-technical stakeholders to elicit needs and drive alignment without holding line authority over them.
• Fluency working within, and respecting, standards set by infrastructure, engineering, and security functions.
• Excellent communication skills across both executive and hands-on technical audiences. Comfort operating with ambiguity and broad scope in a lean, fast-moving environment.
• Demonstrated ability to utilize AI tools for day-to-day work; baseline proficiency is expected, and advanced or innovative use of AI is a strong plus.

Preferred

• Experience in life sciences, biotech, or another regulated industry, with exposure to Clinical Development workflows and clinical data.
• Familiarity with GxP, data integrity (ALCOA+), HIPAA, SOX, or SOC2 expectations as they shape system and data design.
• Experience with platforms common in clinical and enterprise environments, for example clinical, eTMF, or EDC systems, integration and data platforms, and workflow or document management tooling.
• Prior experience as an internal architect or consultant brought in to untangle organically grown systems.

Core Values

• Growth-Minded . We're inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent. We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In. We're All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

The base salary range for this position is $165,000-$195,000, depending on experience, qualifications, and internal practices. Parabilis's total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees' overall well-being.

As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.