Chief of Staff
Sapiom
About Sapiom AI agents are beginning to act on behalf of companies and users — making purchases, spinning up compute, triggering workflows, and interacting with third‑party systems. But today’s financial infrastructure was built for humans, not autonomous systems. Companies and developers need a way to give agents controlled access, meter actions, monetize usage, and transact across rails, without rebuilding payments, risk, and compliance internally. Sapiom builds the financial payments infrastructure for the machine economy — autonomous spend rails that enable AI agents to transact with real‑world services safely, processing every dollar spent, every policy decision navigated, and every risk signal generated. We have assembled a world‑class team with deep payments and infrastructure DNA to build the operating system for machines. Backed by a $15.75M investment from Accel, Menlo, and Anthropic, we are moving with relentless focus to deploy the economic substrate for autonomous agents. About the Role Chief of Staff to the CEO — a high‑trust, high‑agency role at the center of the company. The CEO architects the product and vision; you architect the operational backbone that lets the company scale. You’ll embed deeply in the day‑to‑day mechanics of the business, translating founder intent into execution, tracking progress relentlessly, and removing bottlenecks before they slow the team down. What you will do You’ll debate strategy with the CEO and drive operational execution, with the judgment and trust to speak on their behalf in high‑stakes situations, internally and externally. You’ll move fluidly across the business — from structuring commercial partnerships and supporting GTM motion, to driving discussion with partner CTOs and representing the product confidently with developers. You treat legal, finance, and people ops with the same rigor as a production system, build processes that are audit‑ready by default, and reach for automating outcomes.. Youbuild teams people insist on joining and hand them off once they are up and running. Responsibilities Serve as an extension of the CEO — translating strategy into clear, trackable initiatives, driving cross‑functional alignment across Engineering, Product, and GTM, and ensuring key priorities move forward with speed and accountability. Architect and systematize the company’s operating functions — finance, legal, compliance, hiring, and ops — building systems designed for hyper‑growth that are audit‑ready by default. Support the commercial engine by structuring Design Partner relationships, defining ICPs, managing GTM cadences, and translating customer discovery into product direction and positioning. Own the capital and narrative layer — synthesizing market signals into a coherent story, preparing board and investor materials, and orchestrating fundraising processes end‑to‑end. Build and lead early‑stage teams across new functions, acting as interim manager until a world‑class domain owner is recruited and the function is handed off. Requirements 10+ years in a high‑execution role — Engineering, Technical Program Management, Product, or Strategy — with a proven track record driving complex, cross‑functional initiatives from idea to completion. Strong technical fluency: able to engage credibly with engineers and partner CTOs, represent the product externally, and identify technical growth opportunities. Demonstrated experience building or scaling business operations (finance, legal, compliance, hiring) in a high‑growth startup environment. Track record supporting or leading fundraising end‑to‑end — data rooms, decks, investor narratives, and diligence management. Experience structuring commercial partnerships: LOIs, ICPs, success criteria, and translating customer discovery into product direction. Comfort pressure‑testing executive thinking in high‑stakes settings — surfaces blind spots and challenges assumptions constructively. Proven ability to design recruiting engines and hiring bars that raise team quality; willing to act as interim leader for new functions. Hands‑on with automation tooling and AI agents — default instinct is to eliminate operational drag through systems, not headcount. Builder’s mentality: designs for 100x scale from day one. #J-18808-Ljbffr
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$281k - $330k
...highly strategic role, you will partner with executives and senior leaders both across the business and within the Product org. As Chief of Staff reporting directly to the CPO, you will have an immediate impact on our CPO’s productivity from day one, streamlining strategic...SuggestedWork at officeLocal areaImmediate startRemote workRelocation3 days per week$206k - $284k
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- ...want to do important work for critical industries on an ambitious, high-energy team, we’d love for you to join us. About The Role Chief of Staff at Heliux will be directly responsible for leading business operations and closely partnering with the CEO to run strategic...Permanent employment
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...Chief of Staff to Chief Strategy Officer Hybrid About Us At Cloudflare, we are on a mission to help build a better Internet. Today the company runs one of the world’s largest networks that powers millions of websites and other Internet properties for customers...Temporary workFlexible hours- ...looking for thoughtful, driven people excited to work at the intersection of AI, Security, and Infrastructure. About This Role As Chief of Staff to the CEO, you'll operate at the center of the company working directly with the CEO and executive team as the company scales...Work at office
- ...liquidity that someone else sold back. So that's what we make: a liquid market for GPU offtake. About The Role SF Compute is seeking a Chief of Staff to the CEO to serve as a strategic partner and force multiplier to the CEO. This role combines strategy, operations, and...Long term contractContract workFixed term contractWork at officeLocal areaVisa sponsorshipShift work
$300 per month
...ambitious team run by scientists and engineers from leading institutions across biology, physics, chemistry, and AI. Role This is Chief of Staff to Sam Rodriques, Edison Scientific's co-founder and CEO. This role is one of the highest-leverage seats in the company: you...Work at office$135k - $175k
...Capital and NVP Capital, looking for builders who want to solve hard problems. The Role & Culture We are seeking a sharp, organized Chief of Staff to support HomeVision’s CEO and company operations. This role is focused on acting as a strategic operational partner to the...Flexible hours- ...years running and grown a high-caliber team turning the art of sales into a scalable science. About the Role We’re looking for a Chief of Staff who will operate as a true extension of the CEO. This is a rare opportunity to work directly alongside the CEO and gain an...
- ...between our ambition and our internal operating foundation is widening, and closing it is now a priority. We are looking for a Chief of Staff to work directly with our CEO: to build the systems the company runs on, own the operational details that cannot slip, and grow...Work at officeShift work
$256k - $320k
...xAI, Notion, Coinbase, and Palantir, among others Build a massive, fast‑growing business with billions in revenue The Role The Chief of Staff to the CEO is one of the highest‑leverage roles at Handshake — a seat at the center of our most consequential decisions as we enter...Full timeFreelanceInternshipWork at officeRemote workFlexible hours- ..., Coinbase, and Palantir, among others Build a massive, fast-growing business with billions in revenue The Role The Chief of Staff to the CEO is Garrett Lord's closest execution partner - the person who helps him get things done at extraordinary speed across...Full timeFreelanceInternshipWork at officeRemote workFlexible hours
- The Role Pair directly with the CEO to scale the company and its impact on patients across the country. Be their force multiplier. Make them 2x more effective, every day. 5 days a week in person in San Francisco. Scope You'll span every topic the CEO touches: ...Work experience placement
- ...Important note: this hiring process is being managed by Hike's current Chief of Staff who is being promoted into a new role. About Hike Medical Hike Medical is building the defining company in musculoskeletal care. We sit at the intersection of AI, robotics, and...Work at officeRelocation package
$180k - $300k
...insurance value chain. This is a unique opportunity to be at the forefront of shaping a new paradigm in AI and insurance. The role As Chief of Staff, you’d sit at the center of the business and work directly with Rushil on the most strategic initiatives across the company....Full timeWork experience placementWork at officeLocal area- ...About the Role Our Client is hiring a Chief of Staff to be the CEO's right hand. The team is growing extremely fast and needs a force multiplier who can take strategic projects and run them end-to-end across growth, fundraising, hiring, expansion, customer success, and...Shift workNight shiftDay shift
$120k - $160k
...About The Role A fast-growing applied AI research startup — building the memory layer for intelligent systems — is hiring a Chief of Staff to work directly alongside the founding team. This is a high-impact, high-visibility role for someone who thrives in ambiguity and...Work at officeVisa sponsorshipWork visaShift work$130k - $170k
...engineering, demos, recruiting, and company-building — and we need someone to keep it organized and driving forward. About the Role As Chief of Staff at Droyd, you will work closely with leadership to keep the company running smoothly. This is a high-leverage operational role...Full time- ...and email Flam Codes: Integrate with physical channels (outdoor ads, CTV, retail stores, events) Job Overview Flam is hiring a Chief of Staff to act as the operational quarterback for the CEO and broader leadership team. You’ll work directly with the CEO and closely support...Shift work
$60 per hour
...We are seeking an experienced Clinical Chief of Staff to serve as the primary operational and administrative partner to the Chief Medical Officer (CMO) . This highly visible role supports the day-to-day success of the clinical organization by coordinating operations,...Contract workMonday to Friday$165k - $205k
...scaling rapidly and building the foundation for a new era of high-performance, Made in America production. About the role: The Chief of Staff is a high-output operator who works directly with the CEO to drive execution across Formic’s highest-priority initiatives. This...Hourly payFull timeTemporary workRemote workHome officeShift work- ...A pioneering AI interpretability research company based in San Francisco is seeking a Chief of Staff to support the leadership team. The role requires exceptional communication skills and the ability to take significant initiatives across various projects. Candidates...Full time
- ...DepthFirst AI, Inc. is seeking a Chief of Staff to the CEO to operate at the center of the company, translating strategy into execution and steering cross‑functional initiatives as the organization scales. In this high‑visibility role, you’ll prepare board materials,...
- ...Chief of Staff Job Posting Starting July 2026 Classification: Regular, Full-time, Non-exempt, 12-month, Staff Reporting to: Head of School The Chief of Staff role at Urban School of San Francisco serves as a key advisor to the Head of School and is a member of the school...Full timePart timeWork at officeLocal areaNight shiftAfternoon shift
$223.86k - $330.72k
...San Francisco, CA TWO OPENINGS! San Francisco Municipal Transportation Agency San Francisco, CA Chief Infrastructure Officer Annual Salary: $223,860 - $330,720 DOE/DOQ Deputy Chief Infrastructure Officer Annual Salary: $210,678 - $311,194 DOE/DOQ The San Francisco Municipal...$100k - $250k
...backed by Floodgate, Peak XV, and YC — and we've been doubling every 3 months since inception. Now we're looking for a cracked Chief of Staff to be the founder’s force multiplier and help run the company. We don't want someone to "manage calendars." We want someone who...Full timeWork at office$150k - $175k
...together. About You Most business education happens from a distance. This role puts you in the room where it's made. We're hiring a Chief of Staff who gets genuine energy from making things run well, and who wants to learn how a real company grows by doing the actual work,...Temporary workWork at officeLocal areaWorldwideMonday to FridayFlexible hours3 days per week
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