Clinical Program Operations Manager

Role Description

Join Natera's Clinical Innovation & Therapeutics team as a Clinical Program Operations Manager. You will be responsible for the operational delivery of the team's oncology trials, including timelines, budgets, vendor performance, site management, and data flow, ensuring that studies are executed on schedule, within scope, and in a continuous state of inspection readiness.

This position is accountable for translating approved protocols into activated sites, enrolled patients, and clean, lockable data. You will work in close partnership with the team's field-based Medical Science Liaison, who leads scientific exchange and investigator engagement, the Head of Clinical Development and Medical Affairs, while you drive vendor oversight, and cross-functional accountability.

Qualifications

• Bachelor's degree in a life science or related field required; advanced degree (MS, PharmD, PhD) preferred
• Minimum of 5 years of clinical research experience, including at least 3 years managing oncology trials in a program or project management capacity
• Demonstrated accountability for at least one oncology study from startup through database lock preferred
• Working knowledge of ICH-GCP, applicable FDA regulations, IRB/EC processes, and trial master file and inspection readiness requirements
• Proficiency with CTMS, eTMF, EDC, and IRT systems, project management tools such as Smartsheet or MS Project, and Microsoft Office
• Experience managing CRO and site contracts, budgets, and change orders
• Experience within small- to mid-sized biotechnology companies preferred
• PMP or equivalent project management certification preferred

Requirements

• Ability to work independently, take ownership of outcomes, and maintain progress under competing priorities and compressed timelines
• Ability to operate without an established playbook, adapting plans as the science, portfolio, and business continue to evolve
• Willingness to engage at a detailed operational level and resolve obstacles proactively
• Reliance on data, including enrollment curves, cycle times, query aging, and vendor performance metrics, to identify root causes of delay and test assumptions
• Ability to guide cross-functional initiatives and build alignment across clinical, medical, and product organizations
• Clear, direct written and verbal communication, including the ability to brief senior leadership concisely and hold vendors accountable to commitments
• Builds and sustains effective working relationships internally and externally
• Requires working with PHI (Protected Health Information) in paper and electronic formats, treating regulatory and quality requirements as foundational
• Completes HIPAA/PHI privacy, compliance, and security training within 30 days of hire and maintains current status on Natera training requirements

Benefits

• Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents.
• Natera employees and their immediate families receive free testing in addition to fertility care benefits.
• Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits, and much more.
• Generous employee referral program!

Company Description

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers, and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.