Vice President, Clinical Development-Neuroscience

Company Overview At Annexon Biosciences we are a biopharmaceutical company advancing a late-stage clinical platform of novel therapies for people living with devastating classical complement-mediated neuroinflammatory diseases of the body, brain, and eye. Our novel scientific approach targets upstream C1q to block the classical complement inflammatory cascade before it starts, and its therapeutic candidates are designed to provide meaningful benefits across multiple autoimmune, neurodegenerative and ophthalmic diseases. With proof‑of‑concept data in Guillain‑Barré syndrome, Huntington’s disease and geographic atrophy, we are rigorously advancing our mid‑to late‑stage clinical trials to bring new potential treatments to patients as quickly as possible. Position Vice President, Clinical Development – Neuroscience We are seeking an accomplished and visionary leader to join our team to drive the clinical strategy and execution of the portfolio of programs in neurodegeneration and neuro‑immunologic diseases. The role will involve strategy for the investigation of clinical candidates in this therapeutic area and support end‑to‑end design and execution of clinical programs, from Phase I through Phase III, ensuring scientific integrity, regulatory compliance, and alignment with corporate objectives. The successful candidate will collaborate with cross‑functional teams, lead clinical aspects of regulatory submissions, and establish critical partnerships with key opinion leaders and external stakeholders to advance clinical initiatives. Responsibilities Lead the strategic direction and execution of the portfolio of neuroscience clinical development programs, from early‑phase through late‑stage ensuring scientific robustness and regulatory compliance. Collaborate cross‑functionally with research, regulatory, pharmacovigilance, biometrics, clinical pharmacology, medical affairs and operations to ensure successful execution of clinical development plans. Drive preparation, submission and management of regulatory filings, including trial applications, investigator brochures, study protocols and marketing authorization dossiers (BLA/NDA, MAA) in alignment with global guidelines (FDA, EMA). Analyze, interpret and communicate data to inform key decisions, providing clear recommendations and guiding clinical development strategy. Establish and maintain strategic relationships with key opinion leaders, clinical investigators and external stakeholders to advance clinical initiatives. Manage clinical trial budgets, timelines and resources, ensuring high‑quality results aligned with corporate objectives. Present clinical progress, data outcomes and strategic recommendations to executive leadership, stakeholders and external partners on a regular basis. Stay at the forefront of industry trends, scientific advances and regulatory developments to keep the company competitive. Identify potential risks in timelines, budgets or regulatory pathways and develop contingency plans to mitigate them. Required Qualifications MD or MD/PhD with board certification in Neurology, Neuroscience or related field. 15–20 years of experience in clinical development for CNS‑related indications. Proven leadership in designing, managing and executing clinical trials from early phase through late‑stage development. Experience leading clinical development teams at a senior or executive level, ideally in a high‑growth biotech or pharmaceutical environment. In‑depth knowledge of global regulatory requirements and guidelines (FDA, EMA) and clinical development processes, including experience with HA meetings, briefings and regulatory submissions. Exceptional leadership, strategic thinking and communication skills with a track record of influencing across functions. Ability to work effectively in a fast‑paced, dynamic environment and manage multiple priorities. Strong analytical and problem‑solving skills, data‑driven approach to decision making. Demonstrated success in building collaborations with cross‑functional teams and external partners. Preferred Qualifications Experience with regulatory submissions and trial oversight in a biotech or pharmaceutical setting. Familiarity with emerging trends in neurology, including cutting‑edge therapeutic modalities. Salary and Location Salary Range: $399,600 – $427,500 USD Location: Brisbane, California (preference for San Francisco Bay Area candidates) Benefits Flexible work schedules, remote opportunities and work‑life balance. Shuttle service from BART, Caltrain and Ferry. Competitive base salary, equity participation, employee stock purchase plan and comprehensive health benefits (medical, dental, vision, 401(k), flexible spending plans). Annexon Biosciences is an Equal Opportunity Employer and prohibits discrimination or harassment of any kind. We are committed to fostering an environment where all people are welcome and supported. We cultivate a culture of inclusion for all employees that respects individual strengths, views and experiences. We believe that our differences enable us to be a better team—one that makes better decisions, drives innovation and delivers better business results. Creativity and innovation flourish in an environment of openness, inclusion and mutual respect. #J-18808-Ljbffr Annexonbioscience