Advisor, Biotransformation - Novel Modalities

Job ID: R-108853Company: LillyLocation: Indianapolis, Indiana, United States of AmericaJob Type: Full TimeCategory: Research & DevelopmentPosted Date: 2026-07-21At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us. Biotransformation (BTx) Advisor role based in IndianapolisThe Research Advisor, Biotransformation Scientist is an individual-contributor role that combines scientific leadership with continued, hands-on proximity to data generation and experimental work. Working with the Biotransformation group lead, the scientist personally designs, implements, and interprets Discovery and/or Development biotransformation studies for oligonucleotides, siRNA, and other novel modalities (e.g. ADCs, peptide conjugates, ARCs) within the investigative ADME/Tox organization, while providing deep scientific and project-level direction in conjunction with Program Leads to ensure activities are aligned with the organization's goals. The scientist may represent Eli Lilly and Company in external collaborations, conferences, and industry forums, contributing to the advancement of knowledge in the field. Ultimately, this role is critical for driving scientific excellence and strategic growth within the biotransformation group, ensuring that our drug discovery and development efforts are efficient, innovative, and impactful.Responsibilities: Bring deep technical expertise in oligonucleotide, siRNA, and other novel-modality biotransformation to build and strengthen a team of biotransformation scientists supporting Discovery and Development projects.Personally design, implement, and interpret biotransformation and bioanalytical studies for oligonucleotide, siRNA, and other novel-modality programs, remaining directly engaged in data generation and experimental work.Lead biotransformation tasks in designing and delivering biotransformation studies both internally and externally at CROs.Ensure high-quality data is generated by both internal and external sources.Understand, influence and apply regulatory guidance relevant to biotransformation/metabolism studies.Develop and implement strategic plans for biotransformation project support.Communicate the interpretation and impact of biotransformation results across ADME/Tox, project teams, and management effectively.Collaborate in a fast-paced work environment with internal staff and external CROs. Mentor junior staff.Engage in the external scientific community.Qualifications: PhD in analytical chemistry, or related field with 5-7+ years of hands-on work experience in biotransformation and drug metabolism, specifically in the field of oligonucleotides, siRNA, and other new modalities, including bioanalytical and metabolite-identification techniques (e.g., LC-MS/MS, hybridization-based assays). Additional Skills/PreferencesDemonstrated experience supporting biotransformation and/or bioanalysis of new modalities (i.e. ADCs, peptides, RNA, siRNA, ARCs).Deep understanding of biotransformation, and drug metabolism impact on moving compounds from Discovery through IND to NDAExperience with regulatory guidance(s) for drug development. Demonstrated experience experimental biotransformation and/or bioanalysis of new modalities (i.e. ADCs, peptides, RNA, siRNA, ARCs)Experience with specific MS analysis software for new modalities (e.g. BioPharm Finder, MassMetaSite)Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form () for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (View email address on click.appcast.io), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is$151,500 - $244,200Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.#WeAreLillySkillsbiotransformationdrug metabolismoligonucleotide studiessirna studiesbioanalytical studiesmetabolite identificationlc-ms/msregulatory guidanceexperimental designdata interpretationcro collaborationbiopharm findermassmetasitestrategic planningmentoringscientific communicationproject leadershipcollaboration