Supply Chain Planning Manager

Our mission is to detect cancer early, when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative, safe, and effective technologies that can transform cancer care. We are a healthcare company, pioneering new technologies to advance early cancer detection. We have built a multi‑disciplinary organization of scientists, engineers, and physicians and we are using the power of next‑generation sequencing (NGS), population‑scale clinical studies, and state‑of‑the‑art computer science and data science to overcome one of medicine’s greatest challenges. GRAIL is headquartered in the Bay Area of California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies. The Supply Chain Planning Manager is responsible for managing complex planning activities and driving operational excellence across material flow end‑to‑end. This role operates with a high degree of independence, providing expertise, resolving significant planning and supply chain challenges, and contributing to strategic initiatives. The incumbent partners closely with cross‑functional teams, and plays a key role in improving efficiency, reducing costs, and ensuring material continuity. This role is based at our Durham, North Carolina office and offers a flexible working arrangement, with the ability to work from GRAIL's office or from home. Our current flexible work arrangement policy requires that a minimum of 60% of your total work week be on‑site. Your specific schedule, determined in collaboration with your manager, will align with team and business needs and could exceed the 60% requirement for the site. Responsibilities Conduct advanced demand and inventory analysis to develop replenishment strategies, optimize working capital, and reduce risk of supply disruptions. Responsible for a specific set of inventory items from end‑to‑end (planning, acquisition (through procurement), inventory receipt (through warehouse), material transfer approvals (as required), work orders (per the direction of leadership), etc.). Expected to understand and analyze demand forecasts, historical usage, and system variances, identifying risks, and developing recommendations that support optimal material availability. Strong expertise in Bill of Materials (BOM) management in MRP software platforms, maintaining records for vertically integrated material relationships. Develop and deliver supply chain performance reports and dashboards, providing insights and recommendations to management for strategic decision‑making. Lead project‑based work throughout the year (e.g., S&OP process owner, safety stock process owner, ERP process owner). Act as a subject matter expert on planning and supply chain processes and systems, advising internal stakeholders on best practices and solutions. Lead resolution of significant material issues, escalating when necessary and ensuring minimal business disruption. Partner with cross‑functional teams on process optimization, supply chain automation initiatives, cost savings, and operational improvements. As applicable, mentor and provide guidance to junior specialists and coordinators, sharing knowledge and expertise to build team capability. Ensure compliance with company policies, industry standards, and applicable regulatory requirements. Adaptability and Growth Expectation As our organization continues to evolve and grow, this role may require flexibility in responsibilities and duties. Employees should expect that their role may expand, shift, or be modified to meet changing business needs, strategic priorities, and organizational objectives. Taking on additional responsibilities. Participating in cross‑functional projects and initiatives. Adapting to new technologies, processes, or methodologies. Supporting other departments or teams during periods of high demand. Contributing to special projects or temporary assignments as needed. These job duties are a summary of the primary duties and responsibilities of the job and position. It is not intended to be a comprehensive or all‑inclusive listing of duties and responsibilities. Contents are subject to change at the company's discretion. Required Qualifications Bachelor’s degree in Supply Chain Management, Business Administration, Operations Management, or a related field; OR a Master’s degree in a related field. 6+ years of relevant work experience in supply chain, procurement, logistics, or related function; OR a Master’s degree with 3+ years of relevant experience; OR a PhD in a related field with 2+ years of relevant experience. Advanced proficiency in ERP and supply chain management systems, with strong knowledge of reporting and analytics tools. Demonstrated level of knowledge regarding applicable regulatory standards commensurate with the position's complexity and scope, contributing to organizational regulatory compliance. Occasional travel may be required for supplier meetings, site visits, or project execution. Preferred Qualifications 8+ years of relevant work experience in supply chain, procurement, logistics, or related function; OR a Master’s degree with 5+ years of relevant experience; OR a PhD in a related field with 2+ years of relevant experience. Minimal applicable standards for this position include: GMP quality management systems (e.g. ISO13485) Clinical laboratory regulations (e.g. CAP, CLIA, NYSDOH, ISO15189) Operations within the regulated medical device environment (e.g. IVDD, IVDR, FDA21CFR800 series, FDA21CFRPart11) Advanced background in MRP and Excel based material modeling solutions, including the use of scripting languages to create customized solutions. Strong analytical and problem‑solving skills to address complex planning challenges. Proven ability to lead cross‑functional initiatives and drive measurable process improvements. Advanced organizational and prioritization skills to manage competing priorities in a dynamic environment. Leadership ability to mentor junior staff and act as a resource for the broader team. High attention to detail; organized with the ability to keep track of many different activities at one time. Have excellent communication skills, both written and verbal. A strong ability to influence internal stakeholders. Thrive in a dynamic environment. Team player and a collaborative peer. Physical Demands & Working Environment Standard office environment with frequent use of ERP systems, data analysis platforms, and reporting tools. Periodic work in warehouses, distribution centers, and operational areas to oversee logistics and inventory processes. Regular external interaction with suppliers. Occasional travel may be required for supplier meetings, site visits, or project execution. Hours and days may vary depending on operational needs. Standing or sitting for long periods of time may be necessary. May be exposed to hazardous materials, blood specimens and instruments with moving parts, heating or freezing elements, and high speed centrifugation. Some lifting (up to 25pounds) may be necessary. The expected, full‑time, annual base pay scale for this position is $118K–$156K. Actual base pay will consider skills, experience, and location. This role may be eligible for other forms of compensation, including an annual bonus and/or incentives, subject to the terms of the applicable plans and Company discretion. This range reflects a good‑faith estimate of the range that the Company reasonably expects to pay for the position upon hire; the actual compensation offered may vary depending on factors such as the candidate’s qualifications. Employees in this role are also eligible for GRAIL’s comprehensive and competitive benefits package, offered in accordance with our applicable plans and policies. This package currently includes flexible time‑off or vacation; a 401(k) retirement plan with employer match; medical, dental, and vision coverage; and carefully selected mindfulness programs. GRAIL is an equal employment opportunity employer, and we are committed to building a workplace where every individual can thrive, contribute, and grow. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, gender, gender identity, sexual orientation, age, disability, status as a protected veteran, or any other class or characteristic protected by applicable federal, state, and local laws. Additionally, GRAIL will consider for employment qualified applicants with arrest and conviction records in a manner consistent with applicable law and provide reasonable accommodations to qualified individuals with disabilities. Please contact us at View email address on click.appcast.io if you require an accommodation to apply for an open position. GRAIL maintains a drug‑free workplace. We welcome job‑seekers from all backgrounds to join us! #J-18808-Ljbffr