Senior Safety Scientist

Revolution Medicines is a late‑stage clinical oncology company developing novel targeted therapies for patients with RAS‑addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC‑6236), a RAS(ON) multi‑selective inhibitor; elironrasib (RMC‑6291), a RAS(ON) G12C‑selective inhibitor; zoldonrasib (RMC‑9805), a RAS(ON) G12D‑selective inhibitor; and RMC‑5127, a RAS(ON) G12V‑selective inhibitor, are currently in clinical development. Opportunity The Senior Safety Scientist within Global Patient Safety Science is an individual contributor who provides safety science and pharmacovigilance support to all products across the RevMed portfolio, which includes early and late phase development activities. The individual will be responsible for safety oversight of clinical studies, review and authoring of clinical trial protocols, IBs, ICFs, and DSURs. Additional safety‑related activities include medical review of individual case safety reports (ICSRs), safety surveillance of assigned products, and active participation in cross‑functional teams. The Senior Safety Scientist will develop and maintain an understanding of the safety profile of the assigned product(s). Responsibilities include: Proactive medical safety surveillance of ongoing clinical trials for identification and management of safety incidents Prepare and present safety data summaries to internal and external stakeholders Risk management activities, including medical review of IC (and routine review of safety data and pertinent scientific literature) Acquire and contribute knowledge of relevant drug class and/or competitor safety issues Identify potential clinical safety issues and recommend appropriate risk mitigation measures Involve in preparation and maintenance of relevant sections of clinical trial protocols, IBs (including the reference safety information section), ICFs, DSURs, RMPs, CCDS, and labelling as required Perform safety review of clinical protocols, IB, ICF, and other related documents to ensure alignment with the safety strategy and risk management plan Accountable for the safety components of study reports (i.e., CSRs), publications, aggregate reports, and other regulatory documents Conduct signal detection and evaluation activities for assigned products for continuous benefit‑risk evaluation throughout the product lifecycle and contribute or lead preparation for escalation to safety governance committees Support implementation of decisions from the signal evaluation process, including updates to core safety information, Investigator’s Brochure, and other key safety documents and deliverables Contribute to input related to regulatory filings, New Drug Applications (NDAs), Biologics License Applications (BLAs), and responses to safety queries from third parties such as regulatory agencies Establish and maintain collaborative working relationships with all key stakeholders (study team members, CROs, investigators, study sites, vendors, committees, etc.) Consistently comply with all governing laws, regulations, RevMed standard operating procedures (SOPs) and other guidelines Required Skills, Experience and Education A relevant postgraduate qualification (e.g., MD, PharmD, PhD/MSc in a Life Sciences discipline, or other post‑graduate health professional qualification) 3 or more years of drug development experience in the pharmaceutical or related industry with at least 1 year in drug safety Proven success in creating and sustaining strong relationships with internal and external business partners across an organization to create positive partnerships Broad understanding of the scientific aspects of safety, pharmacovigilance (including GVP, GCP), and clinical/patient risk management and safety operations Demonstrated ability to lead and influence, with and without authority, in a fast‑paced environment Strong presentation skills, effective at summarizing and presenting the key considerations and decision points Thrives in a collaborative team setting and is driven by a desire to deploy innovative approaches and technologies in a high‑energy environment Detail‑oriented with ability to prioritize tasks and function independently as appropriate Strong organizational skills and an ability to interpret, discuss, and report trial‑level data effectively and identify trends Excellent written and verbal communication skills Base Pay Salary Range The base pay salary range for this full‑time position for candidates working onsite at our headquarters in Redwood City, CA is $164,000 – $205,000 USD. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market in which a candidate is based. Individual base pay salary is determined by multiple factors, including job‑related skills, experience, market dynamics, and relevant education or training. Please note that the base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Equal Opportunity Employer Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, ancestry, age, disability, marital status, medical condition, and veteran status. #J-18808-Ljbffr Revolution Medicines