Senior Scientist, Quantitative Systems Pharmacology

Position Overview Senior Scientist, Quantitative Systems Pharmacology – Spring House, PA (on-site, 5 days a week). The QSP Senior Scientist will lead and apply mechanism-based PK/PD and Quantitative Systems Pharmacology (QSP) modeling to support translational and clinical drug development across multiple therapeutic areas. This role integrates modeling, simulation, and data-driven insights to guide dose selection, study design, and strategic decision-making across early and late-stage programs. Responsibilities Scientific Leadership & Modeling Excellence Lead development and application of QSP, PBPK, and PK/PD models to address critical drug discovery and development questions across stages. Design and execute population PK/PD and mechanistic modeling strategies to inform clinical pharmacology plans and regulatory submissions. Conduct exploratory modeling analyses with rapid turnaround to support high-impact decisions. Demonstrate strong scientific rigor in model development, validation, interpretation, and communication of results. Translational Impact & Development Strategy Drive model‑informed decision-making for study design, dose optimization (e.g., RP2D), and indication prioritization. Contribute to clinical development strategies, including protocol design, modeling components in Phase 2/3 studies, and regulatory responses. Provide mechanistic insights linking exposure‑response relationships to clinical outcomes and formulation strategies. Emerging Modalities & Platform Innovation Expand QSP capabilities across advanced and complex biologics modalities such as ADCs, next‑generation conjugates, bispecific/multispecific T‑cell engagers, immune‑targeting biologics, cell therapies, and targeted protein degradation. Support dose strategy, early asset evaluation, and platform modeling frameworks. Develop modeling approaches for next‑generation therapeutic modalities and apply AI/ML‑enabled workflows to enhance scalability and insight generation. Collaboration & Cross‑Functional Leadership Serve as a key modeling representative on cross‑functional teams spanning clinical pharmacology, translational medicine, discovery, and clinical development. Partner with internal and external stakeholders, including CRO oversight and collaboration. Provide scientific mentorship and technical guidance to junior scientists. Scientific Contribution & Innovation Contribute to methodological innovation and model‑informed drug development (MIDD) strategies. Establish scientific credibility through publications, presentations, and external engagement. Advance internal modeling platforms and best practices to improve reproducibility and efficiency. Requirements & Qualifications Education : Ph.D. in Pharmaceutical Sciences, Systems Biology/Pharmacology, Mathematics, Engineering, or a related discipline. Ph.D. candidates with Experience applying quantitative approaches to describe biological systems and enabling rational drug development. Excellent understanding of advanced mathematical modeling and simulation, including numerical methods, parameter estimation/optimization, and ordinary differential equations. Proficiency in Matlab/SimBiology. Strong scientific communication skills and a collaborative, collegial attitude. Preferred Qualifications Experience building, validating, and using QSP models or deterministic models of biological pathways/systems. Knowledge of pharmacokinetics and pharmacodynamics for both conventional and novel therapeutic modalities. Familiarity with AI/ML‑enabled modeling workflows or large‑scale data integration approaches. Experience with general programming and data analysis tools/languages such as R. Strong publication record. Ability to lead projects independently while influencing broader team strategy. Scientific curiosity and commitment to continuous innovation and learning. Company Commitment to Diversity and Inclusion Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. #J-18808-Ljbffr 6084-Janssen Research & Development, LLC Legal Entity