Associate Researcher I-Psychiatry Dr. Kaji

Job Description The laboratory studies human brain development and neuropsychiatric disease using stem cell–derived organoids and primary fetal tissue. Current projects focus on: Defining how radial glia give rise to hippocampal and neocortical lineages, and identifying signaling pathways (e.g., Wnt and beyond) that govern hippocampal subfield specification Building and characterizing human hippocampal organoid systems, including efforts to engineer missing subfields (e.g., CA1/CA3/DG) Identifying conserved molecular and cellular programs across genetic and pharmacologic models of schizophrenia using large-scale single-cell and multiomic datasets Modeling neurodevelopmental contributions to schizophrenia through perturbation systems, including chronic and acute NMDA receptor inhibition (e.g., ketamine exposure) Generating samples for large-scale single-cell and multiomic analyses The long-term goal is to establish a reproducible, high-throughput human organoid platform that enables mechanistic dissection of brain development and convergent disease biology. Qualifications B.S. or B.A. in a STEM-related field Prior experience in a laboratory setting (academic or industry) Basic knowledge of molecular biology and cell culture techniques Strong organizational skills and attention to detail Ability to follow protocols carefully and maintain detailed records Willingness to learn stem cell and organoid methodologies Interest in neuroscience, development, or disease modeling Preferred experience Required Experience with tissue culture and/or molecular biology techniques Familiarity with sterile technique and basic lab practices Experience with microscopy and basic imaging preferred Prior experience with stem cells or organoids is preferred but not required Exposure to sequencing workflows or genomics is a plus but not required Responsibilities This position will support the development and execution of stem cell–based experimental workflows under the guidance of senior laboratory personnel. Responsibilities include: Maintenance of human pluripotent stem cell cultures (hiPSCs/hESCs) Generation and routine maintenance of 3D brain organoids (neocortical and hippocampal) Execution of established differentiation protocols and assistance with optimization of culture conditions Implementation of signaling perturbation experiments (e.g., small molecules, growth factors) Processing of organoid and tissue samples for downstream applications, including: single-nucleus RNA sequencing (snRNA-seq) single-nucleus ATAC sequencing (snATAC-seq) multiomic and spatial assays (sample preparation) Organoid characterization using: immunohistochemistry basic microscopy and imaging Maintenance of accurate laboratory records and adherence to established protocols and SOPs General laboratory responsibilities, including reagent preparation, inventory management, and equipment maintenance Collaboration with senior lab members and computational scientists to support ongoing projects Equal Opportunity Employer The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization. Compensation Statement Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $58661 - $80211.02 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits. #J-18808-Ljbffr Mount Sinai Health System