Senior/Executive Director, Integrated Commercial Data Strategy & Launch Analytics

About Stoke:

Stoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body's potential with RNA medicine. Using Stoke's proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke's first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke's initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke's proprietary approach. Stoke is headquartered in Bedford, Massachusetts. For more information, visit

Position Purpose:

The Executive Director, Integrated Commercial Data Strategy & Launch Analytics will establish and lead Stoke's centralized commercial and patient services data strategy for the launch of zorevunersen. This role will create the integrated data spine, KPI governance, CRM data strategy, field execution reporting, and source-of-truth launch analytics model needed to manage launch readiness and performance across Commercial Operations, Patient Services, Market Access, Medical, Field Leadership, IT, and external partners.

This role owns the data foundation, metric consistency, operational analytics, patient journey reporting, field execution analytics, and launch KPI infrastructure that enable cross-functional decision-making. The role will partner closely with Commercial Insights, which retains ownership of market research, forecast assumptions, market interpretation, and the commercial narrative.

Key Responsibilities:

Centralized Data Strategy & KPI Governance

• Design and lead an integrated commercial and patient services data strategy so launch teams operate from consistent, governed metrics and definitions.
• Build and maintain a KPI dictionary across the patient journey, site readiness, field execution, access and reimbursement, distribution, treatment initiation, persistence, and launch performance.
• Establish a cross-functional governance model to align metric definitions, reporting standards, data quality expectations, and executive launch reporting.

Data Integration & Source-of-Truth Reporting

• Serve as business owner for the commercial data spine, partnering with IT, field leadership, Patient Services, Market Access, Medical, data engineering, CRM platform owners, and vendors to connect hub, specialty pharmacy, CRM, claims/APLD/EMR, 3PL/distribution, field activity, site readiness, and patient journey data.
• Define business requirements for master data, account/HCP/site/payer/patient matching, hierarchy management, data quality checks, ingestion rules, and dashboard logic.
• Ensure vendor-produced reports are standardized, reconciled, and integrated into Stoke's broader reporting environment rather than maintained as disconnected functional outputs.

Field Execution, CRM & Account Readiness Analytics

• Own the business requirements, KPI framework, and reporting model for CRM-enabled field execution across Sales, Field Reimbursement, Medical/RMDs, and other launch-facing teams, in partnership with functional leaders and IT.
• Establish consistent metrics for target coverage, account engagement, site readiness, field activity, next steps, escalation needs, and account-level launch preparedness.
• Partner with Commercial Operations and Field Leadership to ensure CRM design, data capture, dashboards, and field reporting support launch execution and leadership decision-making.
• Connect field activity, account planning, site readiness milestones, access barriers, and patient journey progression into an integrated view of launch performance.
• Support governance of HCP, account, site, payer, territory, and affiliation data so field teams and leadership are operating from a consistent source of truth.

Patient Journey, Access & Site Readiness Analytics

• Develop patient journey reporting from patient identification/referral through start form, benefits investigation, prior authorization, appeals, scheduling, treatment initiation, maintenance, and discontinuation.
• Partner with Patient Services and Market Access to track case aging, documentation gaps, payer barriers, denial reasons, appeal outcomes, referral-to-start timing, and approval-to-treatment timing.
• Build analytics that connect field activity, site readiness milestones, account engagement, and treatment operations readiness to patient progression and launch bottlenecks.

Launch Performance, Executive Reporting & Cross-Functional Partnership

• Own the source-of-truth launch dashboard framework for launch rooms, business reviews, executive updates, board reporting, and cross-functional action planning.
• Translate complex operational, vendor, field, patient services, and system data into clear reporting that highlights launch performance, risks, bottlenecks, and escalation needs.
• Provide reliable actuals, patient funnel metrics, and launch KPI trends to support forecast updates and scenario planning, while Commercial Insights retains ownership of forecast assumptions, market interpretation, and the forecast narrative.

Vendor & Partner Management

• Manage data, analytics, hub, specialty pharmacy, CRM, data warehouse, and reporting partners to ensure reliable feeds, clear accountability, and high-quality deliverables.
• Partner with Procurement, Legal, Compliance, IT, Patient Services, and Commercial Operations on contracting, data use agreements, reporting requirements, and vendor performance management.

Required Skills & Experience:

• Bachelor's degree required; advanced degree strongly preferred.
• 12+ years of progressive experience in commercial operations, commercial data strategy, patient services analytics, launch analytics, business operations, or related roles within biopharma.
• Rare disease, neuroscience, genetic medicine, specialty pharmacy, hub services, or complex specialty launch experience strongly preferred.
• Demonstrated success building integrated data strategies across CRM, hub, specialty pharmacy, claims, patient services, field activity, payer/access, distribution, and data warehouse environments.
• Experience defining CRM business requirements, field reporting needs, target/account data structures, activity metrics, and launch execution dashboards for specialty or rare disease field teams.
• Strong command of patient journey analytics, case management metrics, payer/access metrics, referral-to-start analytics, site readiness metrics, field execution metrics, and launch KPI design.
• Ability to define metric governance, KPI dictionaries, data quality rules, business requirements, and source-of-truth reporting in an emerging commercial organization.
• Executive presence and ability to communicate complex operational data clearly to senior leaders and cross-functional stakeholders.
• Familiarity with commercial data warehouse platforms and BI/reporting tools; Snowflake, CRM analytics, claims/APLD/EMR data, and specialty pharmacy/hub data experience preferred.

Location(s):

Stoke is located in Bedford, MA, and will be moving to a new location in Waltham, MA by the end of 2026. This position is a hybrid position currently based in Bedford and will later be based in Waltham.

Travel:

This position will require approximately 10% travel.

Compensation & Benefits:

At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.

The anticipated salary range for this role at the Director level $229,000 - $302,00 and at the Executive Director level is $270,000 - $319,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation.

Our benefits package includes medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).

Culture & Values:

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual's needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do.


Interested candidates: Please visit Stoke's website to learn more and apply directly to the position listed on our Career Center:

For more information, visit

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.