Senior Scientist / Principal Scientist Discovery Biology

Key Responsibilities Design, execute, and interpret studies to evaluate pharmacology and address biological questions for drug discovery programs for cardiomyopathy targets. Apply advanced disease models, including patient-derived and gene-edited iPSCs, iPSC-derived cardiomyocytes, and engineered 3D cardiac tissues, to assess target engagement, mechanism of action, and functional rescue. Provide deep biology expertise for cardiomyopathy programs to enable high quality target validation, hit ID, mechanistic pharmacology studies, and translational biomarker development to support project advancement. Collaborate closely with chemistry, in vitro pharmacology, bioinformatics, and translational research teams to advance oligonucleotide therapeutics from discovery through candidate selection. Maintain an active laboratory presence by designing, executing, and troubleshooting key experiments while providing technical leadership to the team. Communicate scientific strategy and program progress to senior leadership, external collaborators, and scientific advisors. Mentor and develop junior scientists through technical coaching, project leadership, and career development while contributing to a collaborative, high-performing research environment. Required Qualifications Ph.D. in Molecular Biology, Cell Biology, Pharmacology, or a related discipline, with 5-10+ years of biotechnology or pharmaceutical drug discovery experience (eventual title commensurate to experience). Demonstration of deep expertise in genetic cardiomyopathies and heart failure, through academic research or active contribution to drug discovery programs in a pharma or biotech setting. Broad expertise in molecular and cellular biology and ability to rapidly master new techniques needed for successful project advancement. Demonstrated experience in preclinical drug discovery programs, with experience and success contributing to multidisciplinary project teams. Experience developing and applying complex cellular models, particularly patient-derived and engineered iPSC systems, cardiomyocyte differentiation, and disease-relevant functional assays. Experience with the design and interpretation of in vivo rodent studies of genetic cardiomyopathy or heart failure. Proven ability to mentor scientists and foster cross-functional collaboration across discovery disciplines. Excellent communication and presentation skills, with the ability to convey complex scientific concepts to diverse audiences. Preferred Qualifications Experience with RNA biology and RNA-targeted therapeutics approaches, including oligonucleotide-based modalities. Experience with cellular biology techniques including high content imaging, immunofluorescence, 3D contractility, MEA studies, etc. Broad expertise in modern molecular biology techniques, including CRISPR genome engineering, viral vector systems (AAV/lentivirus), flow cytometry, next-generation sequencing, and high-content imaging. Strong publication and/or patent record in cardiomyopathy and heart failure or related fields. Demonstrated track record of mentoring scientists, building technical capabilities, and advancing discovery programs from concept through candidate selection. #J-18808-Ljbffr Saturnus Bio