Computational Scientist II

Computational Scientist II Software Guidance & Assistance, Inc., (SGA), is searching for a Computational Scientist II for a contract assignment with one of our premier pharmaceutical clients in South San Francisco, CA. Responsibilities We are seeking a highly motivated and collaborative Computational Scientist to join labs within the firm's Research and Early Development. The successful candidate will derive actionable insights from high-content perturbation screens of ex vivo systems. This role requires a deep understanding of computational methods for analyzing sequencing-based, multi-conditional perturbation data (e.g. Sci-plex, Perturb-seq, CROP-Seq), a passion for innovation, and a commitment to improving healthcare outcomes through cutting-edge technology. Analyze large-scale high-content sequencing-based perturbation datasets Collaborate with interdisciplinary and cross-functional teams including biologists, chemists, data scientists, and other stakeholders. Required Skills PhD degree in quantitative field (e.g., Computational Biology, Bioinformatics, Computer Science, Statistics, Mathematics) or in the physical or life sciences (e.g., Chemistry, Biology) with a strong quantitative focus. Proven track record of analyzing large-scale multi-conditional scRNA-seq datasets Demonstrated interest in problems across biology and chemistry as applied to the discovery and development of treatments for disease. Proficiency in scientific programming in Python. Strong background in statistics, probabilistic modeling and data analysis. Excellent communication, collaboration, and problem-solving skills. Strong publication record and experience contributing to research communities. Preferred Skills Experience with the analysis of Perturb-seq/CROP-seq data, or more generally with CRISPR data Multimodal data integration, in particular between multiple measurement modalities and/or clinical patient data Experience with workflow managers such as nextflow or snakemake Practical experience with working on HPC systems / SLURM SGA is a technology and resource solutions provider driven to stand out. We are a women-owned business. Our mission: to solve big IT problems with a more personal, boutique approach. Each year, we match consultants like you to more than 1,000 engagements. When we say let's work better together, we mean it. You'll join a diverse team built on these core values: customer service, employee development, and quality and integrity in everything we do. Be yourself, love what you do and find your passion at work. SGA