Executive Director, AIRx Program Lead

Job Description Takeda Research is constructing a Lab of Tomorrow built on AI, automation, new ways of working, and talent with the singular vision of delivering differentiated medicines to the clinic at speed and cost. To catalyze these efforts, Takeda is creating two complementary units: AI Research Accelerator (AIRx) and Discovery Automation & Robotics (DAR). AIRx will consist of a dedicated group of experienced drug hunters with the autonomy of a biotech and the resources of a leading pharmaceutical company. It is designed to incubate the future AI‑powered operating models and deliver candidates to the clinic at industry leading speed and success rates. Purpose As AIRx Program Lead, you will the end‑to‑end scientific and strategic direction of 2–3 discovery program(s) within a unit deliberately designed to remove the structural overhead that slows programs down in large pharma. AI‑enabled design, externalized wet lab execution, and a direct line to governance: this is the environment elite drug hunters have been waiting for. You will work alongside top computational chemists, AI/ML specialists, and biology experts in a model where the science— not the governance calendar — drives the pace and progress. Programs here move because the structure is built for speed. Your job is to make sure that speed produces the right medicines. A proven track record of leading at least 3 discovery programs to clinic is required. Accountabilities Lead and manage multiple drug discovery projects; oversee the entire discovery process from target identification to preclinical development and IND Define, articulate, and evolve the program strategy; build the medicine vision and early asset strategy Evaluate and prioritize drug candidates based on scientific, medical, and commercial considerations Lead and enable rapid, AI‑enabled DMTA cycles, ensuring computational design outputs are translated into clear recommendations and fast, decisive go/no‑go outcomes Partner with Clinical and Translational teams to refine asset strategy and ensure clinical line of sight from early discovery Manage external CROs providing services to the project; ensure timelines are met and data is decision‑ready Represent Takeda externally for AIRx; evaluate external opportunities and serve as BD ambassador Ensure programs are delivered at pace with disciplined cost stewardship, contributing to a sustainable, high‑quality pipeline of INDs and informing broader portfolio strategy Qualifications & Competencies Advanced degree in health or life sciences (PhD, MD, or DVM); PhD strongly preferred 15+ years of industry experience with deep subject matter expertise in drug discovery; at least 10 years in scientific leadership roles Proven track record leading 5+ programs across discovery from target inception to Candidate Nomination or beyond; minimum 3 INDs required Deep knowledge of the drug discovery process: target identification, hit‑to‑lead, lead optimization, and IND‑enabling activities Strong AI/ML fluency and digital‑forward scientific mindset; experience integrating AI/ML into drug discovery workflows Excellent and inclusive leadership; able to inspire and motivate teams towards ambitious goals Exceptional communication skills; able to convey complex scientific concepts to senior governance audiences Demonstrated success building strategic CRO partnerships; strong business acumen including regulatory and commercial awareness Additional Information The position will be based in Cambridge, MA. This position is currently classified as “hybrid” by Takeda’s Hybrid and Remote Work policy Takeda Compensation and Benefits Summary We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. For Location: Boston, MA U.S. Base Salary Range: $212,000.00 - $333,190.00 The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. U.S. based employees may be eligible for short‑term and/or long‑term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short‑term and long‑term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well‑being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. Locations: Boston, MA Worker Type: Employee Worker Sub‑Type: Regular Time Type: Full time Job Exempt: Yes It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. #J-18808-Ljbffr Initial Therapeutics, Inc.