Scientist I, Biology

At Lyterian Therapeutics, we are committed to developing medicines for patients in need by co‑opting physiologically‑relevant protein homeostatic mechanisms to regulate genetically‑validated targets. Position Summary As Scientist, Biology you will design, execute, interpret, and troubleshoot cellular screening assays supporting our protein degradation drug discovery platform. You will contribute to target characterization and mechanism of action studies supporting our early‑stage research and discovery programs. By collaborating closely with protein biochemists, biophysicists, and molecular biologists, you will uncover fundamental biology behind targeted regulation of protein homeostasis. Impact You'll Make Design and execute cellular experiments to address scientific questions to progress our programs and contribute to key milestones Design, optimize, and run medium to high‑throughput cellular screening assays Summarize experimental findings and present data clearly and effectively at internal team meetings and external conferences Create, maintain, and use a variety of cell lines. Use automation, high‑content microscopy, and/or flow cytometry to develop our proprietary platform Collaborate and communicate across a diverse scientific team to successfully progress Lyterian goals Qualifications Relevant PhD with 0‑2 years relevant industry experience; Experience may include postdoc; Experience may be substituted for education. Demonstrated expertise in mammalian cell culture techniques including transfection and transient or stable expression of recombinant proteins, CRISPR/Cas9 gene editing, plasmid design, siRNA and shRNA knockdown Experience running assays on automated liquid handlers (Bravo, epMotion, Tecan, etc.) Experience culturing with sterile technique and maintaining high‑throughput cell culture assays Experience with fluorescence and luminescence detection platforms and high‑content microscopy is preferred Experience with high‑throughput data analysis and workflows is a plus Familiarity with CRISPR‑based screening or genome editing techniques and prior experience in these areas is plus Experience with molecular biology techniques including but not limited to: in vitro enzymatic assays, IP assays, qPCR, western blots, FACS, IHC, ELISA, HTRF is a plus Ability to keep detailed and organized records of experimental protocols and results Ability to manage multiple tasks efficiently, communicate clearly, work within departmental groups, and to build open and collaborative relationships Initiative and boldness to dive into a fast‑paced new startup $125,000 - $140,000 a year We encourage candidates of all levels to apply as there is often flexibility on job title and responsibilities. Compensation will be based on a variety of factors, including experience, qualifications, internal equity and location. Lyterian offers a competitive employment package that includes an annual bonus, significant equity, and a generous benefits package including comprehensive health, dental, and vision insurance for our employees and their families, plus a 401K match. At Lyterian, we believe that a diverse, open, and inclusive environment and culture is key to our success. We will not be influenced in recruiting, hiring, promoting or any other employment practices by race, color, citizenship status, national origin, ancestry, sex, sexual orientation, gender identity/expression, age, religion, physical or mental disability, medical or genetic condition, marital status, veteran status, or any other characteristics protected under applicable federal, state and local laws. Lyterian will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable laws. Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place does not create any implied obligation. #J-18808-Ljbffr Lyterian