Principal Scientist II - Pharmacology

Band Level 4 Job Description Summary #LI-Onsite Location: Cambridge, MA This position is located in Cambridge, MA and does not have the ability to be located remotely. Please only apply if this area is accessible to you. Over 40 therapies in the clinic! NIBR Oncology strives to reimagine medicines for cancer patients through a combination of treatment approaches including targeted therapies, immunotherapies, CAR-T, and radioligand therapy. NIBR is seeking an in vivo scientist to join our Oncology Pharmacology team in Cambridge, MA. The successful candidate will join a dynamic, multi-disciplinary team and play a key role in the development and application of in vivo models for evaluating novel cancer therapies and advancing the early-stage drug discovery pipeline. This is a labhead-based position, where the ideal candidate is expected to lead efforts in the design and execution of in vivo anti-tumor efficacy and PK/PD studies aimed at evaluating drug candidates in CDX, PDX, and syngeneic models. Applicants are expected to develop novel in vivo assays to interrogate key scientific questions and deliver high-value translationally relevant data that can inform clinical development. Qualified candidates will have extensive experience in a variety of molecular biology skills. A strong background and expertise in antibody drug conjugates is preferred. We are looking for highly motivated, inquisitive, and creative individuals, who thrive in a highly matrixed work environment, and can effectively communicate within multidisciplinary project teams. Job Description Responsibilities: Design pre-clinical in vivo studies to explore novel hypotheses, screen candidate molecules, and establish proof-of-concept of new modalities Develop in vivo CDX, PDX, and syngeneic models to evaluate anti-tumor activity, PK/PD relationships, relevant biomarkers, and key translational questions Manage associate-level scientists Collaborate with cross-functional project teams Critically analyze and present results within a multidisciplinary team environment Careful adherence to animal protocols and proper documentation of data and methods in electronic laboratory notebook Qualifications: PhD with 5-8 years of research experience as a postdoc or in the pharmaceutical/biotech industry Deep knowledge of antibody drug conjugates Extensive experience working with CDX and PDX xenograft tumor models and/or syngeneic models Expertise in cell culture, PCR, ELISA, western blot, and flow cytometry Strong analytical, communication (written and verbal), and organizational skills, including a proficiency with PowerPoint and commonly used data analysis programs, such as Prism and Excel Novartis Compensation and Benefit Summary: The salary for this position is expected to range between $126,000 and $234,000 per year. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors. Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves. EEO Statement: The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential. Accessibility and reasonable accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to View email address on click.appcast.io call View phone number on click.appcast.io and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Salary Range $126,000.00 - $234,000.00 Skills Desired Analytical Skill, Analytical Skill, Analytical Thinking, Chemical Biology, Chemistry, Clinical Trials, Collaboration, Communication Skills, Curious Mindset, Data, Data Analysis, Design Of Experiments, Detail-Oriented, Drug Development, Drug Discovery, Ethics, Gene Therapy, Immunology, Inventory Management, Laboratory, Lifesciences, Machine Learning (ML), Management, Medical Research, Molecular Biology {+ 10 more} Improving the lives of people living with disease takes more than innovative science. It takes a focus on the needs of people and a community committed to meeting them. It takes a team of people like you. Working together. Learning together. Thriving together. Discover how you can join us in changing people’s lives. Novartis is aware of employment scams which make false use of our company name or leader’s names or recruiter’s names to defraud job seekers. Novartis does not make job offers without interview and never asks candidates for money. If you have encountered a job posting or been approached with a job offer that you suspect may be fraudulent, we strongly recommend you do not respond, send money or personal information. In the context of China Cross-Border Data Transfer (CBDT) policy, if you need to apply for a position in China, please go to the local Recruiting System TaleNov .