Sr Staff Program Manager, MES Custom Software Development Transformation New USA - South San Francisco, CA

Sr Staff Program Manager, MES Custom Software Development Transformation

USA - South San Francisco, CA

Sr Staff Program Manager, MES Custom Software Development Transformation (Hybrid in South San Francisco, CA or Wilsonville, OR)

Summary

Twist Bioscience is embarking on a strategic transformation of its Manufacturing Execution System (MES) to modernize our technology platform, enable operational scalability, and support the evolving needs of our business. We are seeking an experienced Sr Staff Program Manager to drive the strategic planning, cross-functional coordination, and hands‑on execution of this business‑critical initiative. Reporting directly to the Sr Director of Technology Operations, this role will lead the delivery of the MES replatform efforts, bringing structure, Agile delivery discipline, and strong program governance to ensure successful execution. Partnering closely with Technology, Manufacturing Operations, R&D, Quality, and business stakeholders, this individual will be responsible for aligning priorities, managing complex dependencies, and driving decisions.

Key Responsibilities

• Strategic Program Leadership: Lead the overall MES replatform transformation, translating strategic objective into an actionable, integrated program roadmap.
• MES Project Execution: Lead day-to-day execution of the MES replatform, managing timelines, scope, resources, and deliverable milestones.
• Stakeholder Engagement: Partner closely with business users, IT process owners, and external software vendors/agencies to communicate status, align expectations, and resolve cross‑functional issues.
• Budget & Resource Management: Track project expenditures, support financial budgeting, and ensure efficient resource allocation across core initiative tracks.
• Process & Change Optimization: Implement company and departmental procedures that affect immediate operations. Assist with organizational change management to ensure smooth system adoption and transition from legacy platforms.
• Risk & Quality Management: Proactively identify technical, operational, and integration risks. Enforce quality‑control practices, compliance standards, and validation protocols required in manufacturing software environments.

Qualifications

• Education: Bachelor’s degree in Computer Science, Software Engineering, Industrial Engineering, Information Technology, or a related field.
• Overall experience: Minimum of 12 years of experience performing and improving business processes, with a strong focus on manufacturing, life sciences, engineering, or operations.
• Agile & Delivery Expertise: Proven expertise in Agile project delivery frameworks (Scrum Master, SAFe, or PMI-ACP certifications preferred) with a strong track record of facilitating Agile ceremonies and managing iteration cycles.
• Project Leadership: 5 plus years in project or program management leading cross‑functional custom software development teams.
• Solid hands‑on understanding of the custom software development lifecycle (SDLC), modern software architecture principles, and business transformation frameworks. Biotech or pharmaceutical industry experience is preferred.
• Strong leadership, negotiation, and conflict‑resolution skills, with a track record of translating complex manufacturing requirements into actionable software solutions.

Preferred Qualifications

• Certifications: Certified ScrumMaster (CSM), PMI-ACP, or SAFe Agilist.
• Industry Focus: Specialized experience in biotech, pharmaceutical, semiconductor, or advanced discrete manufacturing environments.
• Domain Knowledge: Deep understanding of custom software development lifecycles (SDLC), shop‑floor manufacturing processes, SCADA/PLC integration, and ISA‑95 standards.

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon‑based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.

The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations.

$233,000 - $271,000 USD

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self‑identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiringprocess or thereafter. Any information that you do provide will be recorded and maintained in aconfidential file.

As set forth in Twist Bioscience’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law.

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection.As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measurethe effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categoriesis as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service‑connected disability.

A "recently separated veteran" means any veteran during the three‑year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.