Scientist I/II - HPLC Method Development

Position: Scientist I/II – HPLC Method Development Salary Range: $55,000-$70,000Location: Exton, PA (On-site)About PharmaronPharmaron is a global contract research and manufacturing organization (CRO/CDMO) helping pharma and biotech companies bring new therapies to life. With over 25,000 employees worldwide across 28 locations in the US, UK, China, and Singapore, we support drug discovery through to manufacturing with fully integrated high-quality services.We're proud of the impact we make and just last year, we supported 887 discovery projects, 1,100+ CMC programs, and 1,397 clinical trials across all phases. Our teams are involved in everything from small molecules, ADC's, biologics, and gene therapies and we work with more than 3,300 global customers. To learn more, visit Overview:Join Pharmaron's Bioanalytical Sciences team in Exton, PA, and apply your HPLC method development expertise to challenging drug discovery and development programs.As a Scientist I/II – HPLC Method Development, you will develop, optimize, troubleshoot, and validate chromatographic methods while supporting the analysis of diverse therapeutic molecules. You'll have the opportunity to work across HPLC and advanced analytical platforms while expanding your exposure to bioanalysis, DMPK, regulated studies, and mass spectrometry applications.This opportunity is ideal for an early-career analytical scientist with hands-on HPLC method development experience who wants to deepen their expertise in chromatographic method development, complex separations, troubleshooting, and bioanalysis within a global CRO/CDMO environment.Key ResponsibilitiesDevelop, optimize, troubleshoot, and validate HPLC-based analytical and bioanalytical methods supporting drug discovery and development programs.Design and optimize chromatographic conditions, including column selection, mobile phases, gradients, flow rates, and other method parameters to achieve appropriate separation, resolution, sensitivity, and reproducibility.Troubleshoot chromatographic challenges related to peak shape, resolution, selectivity, sensitivity, carryover, retention, and method performance.Perform analytical and bioanalytical sample analysis using HPLC and other available analytical platforms.Design and execute scientifically sound experiments aligned with study requirements, client objectives, and internal quality standards.Process, analyze, interpret, and report chromatographic data while identifying and resolving technical challenges.Support method qualification and validation activities and ensure appropriate scientific documentation of experimental procedures and results.Review and execute study protocols and contribute to protocols, validation reports, technical summaries, study reports, and other scientific documentation.Support developmental and regulated laboratory activities in accordance with applicable procedures and quality requirements.Collaborate with scientists, project teams, management, Business Development, and clients to support successful project execution.Participate in scientific project reviews, technical discussions, troubleshooting activities, and continuous improvement initiatives.Gain exposure to advanced bioanalytical and mass spectrometry applications as experience and project needs develop.What We're Looking ForBachelor's degree or higher in Analytical Chemistry, Chemistry, Pharmaceutical Sciences, Biochemistry, or a related scientific discipline.1–3+ years of relevant analytical or bioanalytical laboratory experience; position level will be determined based on experience and demonstrated technical capabilities.Hands-on experience developing, optimizing, and/or troubleshooting HPLC/ LCMS methods.Strong understanding of chromatographic principles, including separation, selectivity, retention, resolution, and method optimization.Experience analyzing and interpreting chromatographic data and troubleshooting analytical challenges.Strong analytical thinking and scientific problem-solving capabilities.Ability to accurately document and communicate experimental procedures, results, and conclusions.Strong organizational skills, attention to detail, and ability to work effectively in a fast-paced, collaborative scientific environment.Preferred QualificationsExperience independently developing and validating HPLC methods.Experience with HPLC and/or UHPLC instrumentation and associated chromatographic software.Experience optimizing column chemistry, mobile-phase composition, gradients, and other chromatographic parameters.Experience with additional analytical detection technologies and/or LC-MS applications.Hands-on exposure to LC-MS/MS or high-resolution mass spectrometry is a plus but not required.Experience working within a GLP or other regulated laboratory environment.Experience supporting DMPK, bioanalytical, or pharmaceutical development studies.Experience analyzing small molecules, peptides, oligonucleotides, PROTACs, biologics, or other complex therapeutic modalities.Experience authoring protocols, validation reports, technical summaries, or study reports.Previous CRO, pharmaceutical, or biotechnology industry experience.Experience collaborating with clients or cross-functional scientific teams.Why Pharmaron?Pharmaron is a premier service provider for the life sciences industry. Founded in 2004, Pharmaron has invested in its people and facilities and established a broad spectrum of research, development, and manufacturing service capabilities throughout the entire drug discovery, preclinical, and clinical development process across multiple therapeutic modalities, including small molecules, biologics, and CGT products. With over 25,000 employees and operations in the US, UK, China, and Singapore. Pharmaron has an excellent track record in delivering R&D solutions to its partners in North America, Europe, Japan, and China.Collaborative Culture: You will thrive in our inclusive and collaborative environment, where teamwork and innovation go hand in hand. Here, your voice matters, and your contributions make a real impact. "Employees Number One" and "Clients Centered" are the core cultural values at Pharmaron. Our culture, which sets Pharmaron apart from other organizations, has evolved from our deep commitment to our employees, partners, and collaborators.Benefits: As part of our commitment to your well-being, we offer a comprehensive benefits package:Comprehensive Medical, Dental & Vision Insurance with significant employer contributions401(k) Retirement Plan with generous employer matchingGenerous Paid Time Off (PTO), Paid Sick Leave & Company Holidays to support work-life balanceEmployer-funded Health Savings Account (HSA) contributions (for eligible plans), plus Healthcare & Dependent Care Flexible Spending Accounts100% Employer-paid Employee Life Insurance, AD&D, Short- and Long-Term Disability InsuranceEmployee Assistance Program (EAP), mental health resources, and wellness programsFamily-friendly benefits, including fertility support and maternity resourcesProfessional development and career growth opportunities within a leading global CRO/CDMOHow to Apply:Ready to seize this incredible opportunity? Join us at Pharmaron and be part of a dynamic team driving innovation and excellence in biopharmaceutical research and development. Apply online today!As an Equal Employment Opportunity and Affirmative Action employer, Pharmaron values diversity and inclusion in the workplace, fostering an environment where all individuals are empowered to succeed. Join us in our mission to make a difference in the world of life sciences.#LI-MC1