Post Doctoral Scientist - Molecular Pharmacology

Post-Doctoral Scientist – Molecular Pharmacology Are you looking to make an impact in drug discovery at the frontier of G‑protein coupled receptor science? We are seeking an ambitious post‑doctoral scientist with strong research and communication skills to contribute to a high‑visibility research program in quantitative GPCR pharmacology.We aim to develop new mechanistic models to explain binding mechanisms that existing pharmacological theory cannot adequately describe. In this role, you will: Conduct innovative molecular pharmacology studies to characterize the mechanisms of action of GPCR ligands across multiple receptor systems of therapeutic relevance. Work with and be mentored by industry‑leading molecular pharmacologists, structural biologists, computational scientists, and medicinal chemists. Present findings at internal and external scientific meetings and publish extensively in high‑quality peer‑reviewed journals. Basic Qualifications PhD in pharmacology, biochemistry, biophysics, molecular biology, or a closely related life science discipline with all completed requirements by October 2026. Must be authorized to work in the United States on a full‑time basis; Lilly will not sponsor work authorization or visas. Additional Skills/Preferences Training or background in membrane receptor biology, receptor pharmacology, signal transduction, or quantitative pharmacology. Self‑directed and highly motivated, with a commitment to pursuing both technical excellence and publication goals. Excellent communicator (oral and written) with a strong or developing publication record. Proficient in data analysis, graphing, and scientific reporting (GraphPad Prism, Python, Excel, PyMOL, MOE). Experience with ligand binding techniques (competition, saturation, kinetic assays) in live cell or membrane formats. Experience with cell‑based GPCR signaling assays, including cAMP, IP1, β‑arrestin recruitment, intracellular calcium measurement, or phosphoprotein measurement. Familiarity with quantitative pharmacological modelling or kinetic simulation approaches. Experience with mammalian cell culture and standard molecular biology techniques. Understanding or practical experience of modern structural and computational biology approaches. Interest in the mechanistic and theoretical foundations of receptor pharmacology. Position Details Onsite position based in Indianapolis, Indiana. Fixed‑term position up to 2 years with a possible 2‑year extension. Equal Opportunity Employer Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. We also provide accommodations for applicants with disabilities. If you require an accommodation to submit a resume for a position at Lilly, please complete the accommodation request form on our career website. #J-18808-Ljbffr 100 Eli Lilly and Company