Global Development Medical Director, Hematology Oncology

Job Title: Global Development Medical Director, Hematology Location: Boston, MA Hybrid Role: Office based minimum 3 days per week AstraZeneca is a global, science‑led, patient‑focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. We are more than one of the world’s leading pharmaceutical companies. AstraZeneca has a multifaceted environment that cultivates collaboration and innovation. We attract top minds, and we nurture and build talent. Within Hematology R&D, we are committed to advancing the science to deliver life‑changing medicines to patients most in need. With a combination‑focused pipeline that exploits the power of six scientific platforms (Immuno‑Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody‑drug Conjugates, Cell Therapy and Epigenetics) to help address unmet clinical needs in a host of hematological cancers, we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of death. This unit has responsibility for the value chain from discovery through to late‑stage development, enabling rapid acceleration of promising early‑stage assets and life‑cycle management programs. Responsibilities Responsible for ensuring the risk‑benefit of a clinical study, ensuring that all clinical studies operate to the highest ethical and safety standards and in compliance with FDA, EMEA, ICH and GCP guidelines as well as AZ SOPs regarding safety. Work cross‑functionally and lead all aspects of the design and implementation of clinical hemato‑oncology projects, as a leader of our Clinical Product Team (CPT) and member of the Clinical Sub‑Team (CST). Ensure that the overall scientific and medical content of all clinical programs is scientifically and clinically rigorous. Significant contributor to the development of program strategy for assigned compound(s)/programs and work with GPT/CPT members to develop a compelling business case for governance approval. Provide expert clinical input to influence the study design via collaboration with primary investigators, key external experts (KEE), study sites, team members, and internal stakeholders, such that it reflects clinical practice, evolving landscape, regulatory and reimbursement requirements, and meets the strategic program objectives. Participate or lead as needed the review and assessment of new opportunities and ESRs. Accountable for the relevance and accuracy of clinical science underpinning of clinical study based on detailed scientific review and consultation, for the clinical and scientific leadership and integrity of protocols and/or components of clinical plans and for the delivery of final protocol and its governance approval. Provides expert input into/lead the development of the protocol and related documents and the development and delivery of the clinical study report. Full responsibility for the planning, implementation and daily operation of assigned drug development projects in hemato‑oncology. Supports or leads interactions with global medical affairs, marketing companies, commercial, in collaboration with GCH/GCPL to ensure cross functional input into protocols. Responsible for timely responses to investigational study sites for local ICF changes, protocol & EC/IRB questions/requests. Contribute to development and delivery of face to face or virtual investigator and monitor training. Support the development of clinical components of regulatory and EC/IRB submission documents for instances where marketing approval is warranted. Prepare clinical development plans that integrate pre‑clinical and early clinical findings while working to ensure cross‑functional alignment on an ongoing basis throughout the early phases of clinical development. Present and defend protocols and clinical development plans at internal governance forums. Serve as Medical Monitor, responsible for the safety monitoring of clinical trials, and as medical expert for Phase I/II or Phase III studies, innovating the process from protocol development through individual study report and coordinated regulatory documentation. Prepare various official and regulatory documents for Regulatory and other agencies, such as Dossiers, BLAs, INDs, Safety and Annual reports, handling of responses to regulatory agencies regarding questions about complex clinical development issues (e.g., safety or efficacy). Implement clinical R&D policies, SOPs and related directives. Contribute and support Department/Clinical initiatives to improve the quality and content of all clinical programs as well as the cross functional/organization processes designed to effectively deliver our R&D portfolio. Minimum Qualifications MD or international equivalent is required. Minimum of 2 years of relevant experience. Medical hemato‑oncology clinical training is required. Board Certification is preferred. Clinical or research experience (in an academic, pharmaceutical or CRO environment) related to the design and/or conduct of clinical studies in oncology and/or malignant hematology is preferred. Possesses general knowledge of Good Clinical Practice (GCP) and other regulations governing clinical research. Possesses general knowledge of 1) medical monitoring; 2) regulatory approval process in relevant countries; 3) pharmaceutical industry/R&D operations; 4) marketing and commercial fundamentals. Good understanding of clinical trials methodology. Strong communication & presentation skills to clearly communicate scientific concepts/data to leadership committees both internally or externally. Benefits and Compensation The annual base pay (or hourly rate of compensation) for this position ranges from $241,613 to $362,420. Hourly and salaried non‑exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job‑related knowledge, skills, and experience. In addition, our positions offer a short‑term incentive bonus opportunity; eligibility to participate in our equity‑based long‑term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and health benefits including medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at‑will” position and the company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, company or individual department/team performance and market factors. EEO Statement Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. Date Posted 25-Jun-2026 Closing Date 26-Jul-2026 #J-18808-Ljbffr AstraZeneca GmbH