Principal Scientist, Computational Sciences - Protein Structure Prediction and Design

Key Responsibilities Develop and scale antibody design capabilities from prototype to application. Advance agentic antibody design approaches into robust, reusable workflows for preclinical discovery. Build and apply state-of-the-art models for protein structure modeling, binder design, affinity/specificity prediction, and developability property prediction using internal and external datasets. Own end-to-end development of computational pipelines with reproducibility, benchmarking, and maintainable, well-documented code. Partner with computational and wet-lab teams to prioritize capabilities, translate insights into actionable decisions, and communicate clearly to technical and non-technical audiences. Required Qualifications Ph.D. in structural bioinformatics, computational biology, computer science, engineering, physics, or related field + 4+ years relevant industry/academic experience. Expertise in modern ML (e.g., transformers; diffusion/flow generative models) and strong classical ML fundamentals. Experience developing/evaluating predictive models; familiarity with model assessment, benchmarking, and experimental design. Hands-on protein modeling (state-of-the‑art protein structure prediction and generative protein design). Experience with agentic AI frameworks to automate and accelerate research workflows. Strong Python skills; commitment to reproducible research and high‑quality scientific software. Ability to identify high-impact problems; work independently; implement and evaluate solutions. Clear cross-disciplinary communication via visualization and actionable recommendations. Preferred Qualifications Physics-based modeling (e.g., molecular dynamics, freeenergy perturbation) or closed-loop optimization (e.g., Bayesian optimization, active learning). Background in biochemistry, protein engineering, or related experimental disciplines. Compensation/Benefits (highlights) US $156,890–$202,086 (location-dependent); additional incentive cash/stock may be available. Health coverage, wellbeing support, 401(k), disability/life insurance; paid time off. Application Instructions If the role doesn’t perfectly match your resume, they encourage you to apply anyway. #J-18808-Ljbffr Scorpion Therapeutics