Principal Scientist
Scorpion Therapeutics
Role: Principal Scientist leading antibody engineering initiatives within Bristol Myers Squibb's Therapeutic Discovery Sciences Department, focusing on early-stage research and platform technology development for recombinant antibody therapeutics. Responsibilities: design, execute, and troubleshoot workflows for affinity maturation, humanization, format conversion, and characterization of diverse antibody formats (IgG, Fab, scFv, bispecifics) analyze biophysical properties using SEC, SPR/BLI collaborate across discovery, structural biology, computational biology, and other teams evaluate emerging technologies including AI/ML author technical documentation and lead scientific discussions. Requirements: PhD in protein science, structural biology, biochemistry, or related field 4+ years of relevant industry or academic experience hands-on expertise in antibody design, expression, purification, and characterization experience with protein interaction assays like SPR/BLI proven independent experiment planning and troubleshooting skills scientific leadership with impactful publications or patents. Preferred: experience with advanced antibody formats, bioinformatics, structural techniques, and therapeutic areas such as oncology or immunology prior biotech or pharma experience. HighValue: biologics antibody engineering early discovery biophysical characterization platform development cross-disciplinary collaboration. Work setup: laboratory-based role in San Diego, CA. #J-18808-Ljbffr Scorpion Therapeutics
$137k - $235.75k
...and pioneering the path from lab to life while championing patients every step of the way.Learn more at Purpose: The Senior Principal Scientist will be a key member of discovery project teams and interact closely with biology, chemistry, and other drug metabolism and pharmacokinetic...PrincipalFull timeLocal area$143.29k - $266.11k
The PositionThis role is a vital part of our Cell Therapy Process Development team within Pharma Technical Cell and Gene Therapy Development (PTCC), which is committed to advancing next-generation cell therapies through innovative metabolomics research and media optimization...PrincipalFull timeLocal areaRelocation package- Reference: 630468Posted: 2026-09-03Location: San Diego, CaliforniaCompany: Planet Pharma GroupContact: ApplicationsEmail: ****@*****.*** ResponsibilitiesContribute to the design, development, and optimization of LNP formulations for mRNA delivery, including...Principal
$170k - $185k
...cell potency assay methods and product characterization for NK cell products. This role includes leading and mentoring a team of scientists and analysts within the cell potency group, providing scientific oversight of benchtop assay development, detailed documentation...PrincipalFlexible hours- The Principal Scientist, Translational Medicine will play an important role in our organization, leading and managing translational biomarker projects, assessing mechanism of action and PK/PD relationships and supporting the translation of drug discovery programs into the...PrincipalFull time
$144.4k - $216.6k
...specific project needs, enabling capabilities that are not commercially available.We are seeking an experienced and innovative Principal Scientist with expertise in optical design, microscopy, and functional imaging to join our team. This role bridges the disciplines of...PrincipalFull timeSummer workFlexible hours$184.06k - $223.04k
...regarding the asset and disease biologyWorks with TM laboratory scientists and academic TLs to address nonclinical translational... ...please login to your Candidate Home Account.R1601688 : Senior Principal Scientist, Neuroscience, Clinical Biomarker, Late Phases, Translational...PrincipalHourly payFull timeSummer workLive inLocal areaRemote workFlexible hours$120k - $150k
...talented and committed students and postdocs into leading edge scientists. Leveraging the unique scientific environment of Scripps... ...your opportunity to join our transformative team.POSITION TITLE: Principal Scientist (Protein Immunotherapy)JOB SUMMARY: Calibr is seeking...PrincipalFull timeFlexible hours- We are seeking an innovative and highly experienced Principal Scientist in Bioinformatics to lead the design, development, and optimization of advanced PCR-based multiplex assays using cutting-edge computational and AI-driven approaches. This role will combine deep expertise...Principal
$117k - $201.25k
...way.Learn more at & Johnson Innovative Medicine Research & Development LLC, a Johnson & Johnson company, is recruiting for a Principal Scientist, R&D Data, Data Science & Artificial Intelligence (DDSAI) - Immunology. This position will be located at one of our offices...PrincipalFull timeTemporary workLocal areaRemote work- ...of scientific rigor, open collaboration, and continuous learning by openly sharing expertise and providing mentorship to junior scientists. Required QualificationsPhD with 6+ years, MS with 9+ years, or BS with 11+ years of industry experience Track record of strategic...PrincipalSummer holidayLocal areaShift work
$152k - $190k
...state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.Compensation Range: $152K - $190KLocationSan Diego HQEmployment TypeFull timeDepartmentScienceChemistryCompensationPrincipal Scientist$152K - $190KPrincipalFlexible hours$71.25k - $187k
...medicines treating autoimmune diseases and related complicationsPosition Overview:We are seeking a highly motivated and dedicated scientist with knowledge and experience of cellular and molecular biology, who also shares our passion to help patients live with higher quality...PrincipalH1bFlexible hours$156.9k - $214k
Who We Are: Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed...Principal$151.33k - $183.37k
...benefits. This is work that transforms the lives of patients, and the careers of those who do it.We are seeking an accomplished Principal Scientist to advance antibody engineering initiatives within the Therapeutic Discovery Sciences Department on the Protein Engineering...PrincipalHourly payFull timeSummer workLive inLocal areaRemote workFlexible hours$120k - $198k
...Job Description Job Description Title: Senior Scientist / Principal Scientist, Bioprocess Sciences Location: San Diego Job Type: Full-Time About Us: We are an innovative, stealth-mode biotech focused on developing best-in-class delivery for in vivo gene...PrincipalFull time- We are seeking a highly motivated and scientifically rigorous Director of Translational Research to lead translational strategy and execution for our pipeline. This individual will be responsible for identifying and validating development opportunities across multiple disease...PrincipalSummer holidayLocal area
$142.4k - $224.1k
...address significant unmet medical needs. We are seeking anAssociate Principal Scientistwith strong background in Immunology and experience... ...with colleagues and provide mentorship to less experienced scientists to ensure a culture of scientific rigor, collaboration and...PrincipalFor contractorsLocal areaWorldwideRelocationVisa sponsorshipFlexible hoursShift work$114k - $228k
...to work for diversity, working mothers, female executives, and scientists. The OpportunityThis position works out of our San Diego... ..., molecular-based solutions. Position OverviewThe Associate Principal Bioinformatics Scientist is self-driven, working on multiple projects...PrincipalWork at officeWorldwideShift workNight shift$165k - $185k
...Vividion has been recognized as a Top Workplace by The San Diego Union-Tribune from 2022 to 2025. Job Summary: The Principal Scientist, Chemical Development will successfully develop robust synthetic processes and deliver non-GMP & GMP material on multi-kilogram...PrincipalLocal area$169k - $185k
..., potentially curative therapies for conditions with high unmet need. For more information, visit Position Summary The Principal Scientist, LNP Platform & Process Development (Scientist) is an experienced hands-on, lab-based, individual contributor that leads the...PrincipalTemporary work$150k - $220k
Job Description Job Description Description: *Note: exact level depending on experience* Company Overview: Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome...PrincipalLocal area$142.4k - $224.1k
...Job Description The Associate Principal Scientist will lead translational discovery activities through strong expertise in immune cell biology, human disease models, assay development, and data interpretation. The candidate will use primary immune cell systems, ex vivo...PrincipalFull timeFor contractorsLocal areaRelocationVisa sponsorshipFlexible hoursShift work- ...please visit us at . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube. Job Description We seek a Principal Scientist II, Lipid Chemistry to join an experienced, fast-paced and collaborative team focused on developing lipid nanoparticle...PrincipalFull timeTemporary workWork experience placementLocal area
$170k - $240k
...Job Description Job Description Join our fast-paced and passionate team as a Principal Laser Scientist New Laser Development. As we scale, you will be instrumental in building our foundation from the ground up. This is a dynamic, hands-on role for a self-starter who...PrincipalFull timeLocal areaFlexible hours$176.2k - $277.3k
...DVM, MD degree or equivalent. - ~ Minimum 8 + years of demonstrated pharmaceutical industry experience as a non-clinical safety scientist (e.g. Toxicology, Pathology etc.) and/or as non-clinical safety assessment representative to a cross-functional development and/or...PrincipalFull timeFor contractorsLocal areaWorldwideRelocationVisa sponsorshipFlexible hoursShift work- Client is seeking an Analytical Scientist/Senior Scientist (level dependent on experience) to join the Analytical Development Team. The Scientist/Senior Scientist will be responsible for developing, performing, and qualifying analytical methods in support of cellular nanoparticle...
- ...site-specific functionalities for the discovery and development of novel protein-based therapeutics. We are seeking an analytical scientist/mass spectrometrist to utilize and help develop novel analytical, proteomic, and metabolomic methods to optimize unnatural protein...
- ...A leading pharmaceutical company in San Diego is seeking a skilled NMR Scientist. You will utilize advanced analytical techniques, primarily focusing on NMR spectroscopy for small molecule drug development. The ideal candidate has at least 2 years of relevant experience...Contract work
$145k - $165k
...employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The PositionThe Senior Scientist will contribute to the integration of human genetics, multi-omics datasets, and real-world clinical data to generate human...
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