Senior Product Manager, Clinical Genomics

Role Description

Natera is seeking a Senior Product Manager to define and drive strategy for core components of the Results, Interpretation, and Reporting (RIR) platform. This role is responsible for shaping scalable, compliant, and cohesive clinical software systems that support complex genomics workflows across multiple business units. The Lead PM will operate as a platform-level owner, ensuring long-term architectural soundness, regulatory robustness, and measurable clinical and operational outcomes.

Primary Responsibilities

• Define and drive multi-year product strategy and roadmap across one or more RIR components, ensuring alignment to clinical quality, regulatory requirements, and commercial scale objectives.
• Influence platform-level technical direction in partnership with engineering leadership.
• Partner closely with software engineering, bioinformatics, clinical domain experts, quality, regulatory, and other product teams.
• Translate business, clinical, and operational needs into clear, actionable product requirements.
• Define and evolve end-to-end user workflows, including UI/UX requirements and supporting backend functionality.
• Drive cross-team alignment on shared data contracts and workflow standards.
• Mentor and raise the bar for product management within the RIR organization.
• Own measurable improvements in clinical workflow efficiency, reliability, and operational scalability.
• Establish prioritization frameworks that balance regulatory risk, clinical impact, technical scalability, and business outcomes across RIR investments.
• Develop and track quantitative metrics related to usability, performance, reliability, and adoption.
• Lead delivery teams with clear strategic direction, ensuring requirements reflect long-term platform goals, validation readiness, and system interoperability.
• Proactively identify systemic risks, architectural constraints, and workflow inefficiencies that may limit scale or regulatory robustness, and lead cross-functional initiatives to resolve them.
• Partner with Quality and Regulatory leadership to shape validation strategy, risk classification, traceability, and audit readiness for RIR software systems.
• Create clear, data-driven written proposals and presentations to support stakeholder alignment and decision-making.
• Act as a subject matter expert for owned components, supporting design, testing, validation, rollout, and ongoing use.

Qualifications

• Required: Bachelor’s degree in life sciences, engineering, computer science, statistics, or equivalent experience.
• 5+ years of experience in software product management, including ownership of complex, multi-team or platform-level initiatives.
• 5+ years experience working on production software in healthcare, clinical genomics, or other regulated lifesciences domains, with demonstrated impact on validation, compliance, and system scalability.
• Demonstrated experience influencing engineering architecture and long-term technical investment decisions.
• Proven ability to drive alignment across highly matrixed organizations without direct authority.
• Track record of independently operating in ambiguous environments and establishing product direction.
• Preferred: Experience with clinical genomics and variant processing and interpretation workflows.
• Experience owning user-facing applications, tools, or operational software.
• Familiarity working with backend services, APIs, or data-driven systems.

Knowledge, Skills, and Abilities

• Ability to operate effectively at both tactical and strategic levels, connecting detailed execution to broader platform vision.
• Strong analytical skills with attention to quality, reliability, and user outcomes.
• Leads technical design discussions and critically evaluates architectural tradeoffs to ensure scalability, reliability, and regulatory integrity.
• Proven ability to influence without authority and drive alignment across teams.
• Clear, concise written and verbal communication skills across technical and non-technical audiences.
• Ability to manage multiple initiatives in a fast-paced, regulated environment.
• Familiarity with Next Generation Sequencing concepts is beneficial.

Benefits

• Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents.
• Natera employees and their immediate families receive free testing in addition to fertility care benefits.
• Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits, and much more.
• Generous employee referral program.