Senior Scientist, Biology-Discovery, Neuroscience Biomarkers, Mass Spectrometry

Merck's Research & Development Division seeks a Senior Scientist in bioanalytical chemistry to develop and validate mass spectrometry-based biomarkers for neuroscience drug discovery. The role focuses on translational biomarker identification for neurodegenerative diseases using omics approaches within multidisciplinary teams.

Responsibilities

• Develop and apply mass spectrometry assays for preclinical drug development and biomarker discovery
• Plan and execute unbiased and quantitative discovery analyses using high-resolution LC-MS instrumentation
• Collaborate with translational medicine and biology teams to identify and validate fluid biomarkers for patient stratification
• Coordinate assay transfer to internal groups and external contract research organizations
• Train colleagues and serve as technical expert for mass spectrometry applications and new bioanalytical technologies

Requirements

• PhD in Analytical Chemistry or equivalent with minimum four years postdoctoral or industry experience
• Hands-on expertise in unbiased omics (metabolomics, lipidomics, or proteomics) with LC-MS instrumentation
• Proven development and qualification of LC-MS/MS-based quantitative assays
• Proficiency with bioinformatic tools such as MetaboAnalyst, Skyline, MaxQuant, or Proteome Discoverer
• Experience applying mass spectrometry to preclinical models and human biospecimens for biomarker discovery
• Strong collaborative skills and demonstrated ability to produce robust, reproducible data
• Neuroscience degree preferred; drug discovery experience in pharma or biotech preferred

Compensation: $117,000–$184,200 base