Principal Scientist, Translational Clinical Biomarkers
$190.8k - $300.3kMerck
Principal Scientist position leading translational and clinical biomarker strategies across cardiovascular, metabolic, infectious disease, and vaccine development programs. The role involves designing decision-centric biomarker approaches, partnering with cross-functional teams, and translating complex scientific findings into actionable recommendations for program advancement.
Responsibilities
- Develop and lead integrated biomarker strategies across cardiovascular/metabolic and infectious disease/vaccine programs with cross-functional teams
- Translate disease biology and therapeutic mechanisms into translational hypotheses and fit-for-purpose biomarker approaches
- Serve as biomarker representative on program teams, providing strategic input to program-level decision-making
- Lead interpretation of biomarker and clinical datasets, translating findings into clear, actionable recommendations for stakeholders
- Mentor biomarker scientists and support publications, presentations, external collaborations, and expert interactions
Requirements
- Ph.D., M.D., or equivalent advanced degree in translational medicine, biomarker science, or drug development
- Significant experience developing and executing translational or clinical biomarker strategies in drug or vaccine development
- Scientific expertise in cardiovascular disease, metabolic disease, infectious diseases, vaccines, immunology, or related areas
- Ability to lead cross-functional scientific work in matrix environments and influence without direct authority
- Strong analytical and problem-solving skills with ability to synthesize complex datasets into decision-oriented conclusions
- Working knowledge of biostatistics, bioinformatics, quantitative sciences, and multidimensional biomarker data analysis
- Excellent written and verbal communication skills for scientific strategy communication to stakeholders
Vacancy posted 19 days ago
Similar jobs that could be interesting for youBased on the Principal Scientist, Translational Clinical Biomarkers in Upper Gwynedd, PA vacancy
$190.8k - $300.3k
...Merck seeks a Principal Scientist to lead biomarker strategy development across oncology and hematology clinical programs. The role involves designing translational and clinical biomarker approaches that inform key development decisions, from early through late-stage...Principal$173.2k - $272.6k
...Merck seeks a Principal Scientist to lead biomarker strategy development across neuroscience drug development programs. The role involves designing translational and clinical biomarker approaches that inform clinical decisions from early through late-stage development...Principal$260.3k - $409.7k
...have an exciting opportunity for a physician-scientist to join our group as a Principal Scientist (Clinical Director) in Translational Medicine/Early Clinical Development in the... ...Phase 3 clinical trials.Development of biomarker strategies through cross-functional teams...PrincipalFull timeFor contractorsLocal areaWorldwideFlexible hoursMerck Sharp & Dohme (MSD)
West Point, PA4 days ago$260.3k - $409.7k
...Leadership position in translational medicine focused on cardiovascular therapeutic development. Responsible for early clinical strategy from preclinical approval through Phase 2 proof-of-concept, including biomarker development and clinical pharmacology studies in collaboration...Principal$260.3k - $409.7k
...Merck seeks a physician-scientist to lead translational medicine and early clinical development for infectious disease therapeutics. The role bridges discovery... ...trials, requiring expertise in target validation, biomarker strategy, and clinical pharmacology across development...Principal$255.8k - $402.7k
...Merck seeks a physician-scientist to lead translational medicine and early clinical development for neuroscience therapeutics. The role bridges discovery and clinical... ...target validation, clinical trial design, biomarker development, and regulatory support for neurologic...Principal$168k - $199k
...Responsibilities: \n \n Contributes to the scientific development of clinical development programs and individual studies in alignment with... ...internal and external cross-functional stakeholders to ensure translation of the clinical developent strategy and clinical protocol into...PrincipalRelocation packageCSL
King of Prussia, PA5 days ago$117k - $184.2k
...highly motivated bioanalytical scientist at the level of Senior Scientist to support biomarker discovery and validation... ...with a focus on novel target and translational biomarker discovery for neurodegenerative... ..., identify biomarkers for clinical translation and ultimately...Full timeContract workFor contractorsLocal areaMerck Sharp & Dohme (MSD)
West Point, PA4 days ago$255.8k - $402.7k
...Principal Scientist leading clinical research strategy and execution for investigational immunology compounds at a late-stage development level.... ...execution, monitoring, and regulatory submissions Evaluate translational research and develop early clinical development plans...Principal$190.8k - $300.3k
...company's renowned Research and Development division, quantitative scientists, in partnership with other subject matter experts, apply state... ...projects in Late Development Statistics. Interacts with Clinical, Regulatory, Statistical Programming, Data Management, and our...PrincipalContract workWork experience placementLocal areaWorldwideRelocationVisa sponsorshipFlexible hoursShift work$190.8k - $300.3k
...company’s renowned Research and Development division, quantitative scientists, in partnership with other subject matter experts, apply state... ...of patients and global human health Statisticians in the Clinical Safety Statistics (CSS) group develop strategic and statistical...PrincipalFor contractorsWork experience placementLocal areaRelocationVisa sponsorshipFlexible hoursShift work$231.9k - $365k
...a highly collaborative team of scientists (12 anatomic pathologists, 3 clinical pathologists, and approximately... ...toxicology, safety pharmacology, and translational teams to define mechanisms of... ...applicationsContribute to developing novel biomarkers and predictive models to de-risk...PrincipalFull timeFor contractorsLocal area- ...the United States is seeking a Senior Scientist to advance mass spectrometry‑based assays for biomarker discovery in neurodegenerative disease... ...with cross‑functional discovery teams to translate preclinical biomarkers toward clinical applications and drug target...
$282.2k
...Senior Principal Scientist position leading clinical research strategy and execution for oncology drugs across all development phases. Responsible for study design, trial management, regulatory submissions, and cross-functional collaboration within a global healthcare...Principal$255.8k - $402.7k
...Principal Scientist role overseeing clinical research activities for oncology medicines across all development phases. Responsibilities include study design, trial management, regulatory reporting, and cross-functional collaboration to advance new and marketed drugs through...Principal$109k - $174.8k
...more at Position Summary Senior Scientist - Data (AI) Scientist, Translational Safety to join the Data, Data... ...modeling of biological (preclinical and clinical) and RWE data. The Senior... ...models that identify translational-biomarkers and flag compounds with high translational...Work at officeLocal areaImmediate start$190.8k - $300.3k
...Principal Scientist role in Biostatistics leading late-stage clinical development projects. Provides statistical expertise for drug and vaccine development, manages cross-functional teams, and ensures compliance with regulatory requirements throughout the clinical trial...PrincipalWorldwide- Merck in the United States seeks a Senior Scientist to develop and apply mass spectrometry-based assays for biomarker discovery in preclinical neurodegenerative disease... ...work within multidisciplinary teams to drive translational biomarker validation and therapeutic target...
$255.8k - $402.7k
...Merck seeks a Clinical Director (Principal Scientist) to plan and direct clinical research activities for cardiovascular and respiratory medicines across all development phases. The role involves study design, medical oversight, data analysis, regulatory reporting, and...Principal$65k - $95k
...motivated, agile, and experienced scientist with lab level expertise in... ...to join the Cellular Biomarkers Genomics group within the Biomarker... ...biomarker assays in clinical studies. You will generate data... ...and tissues to enhance human translation and predictive value....Hourly payPermanent employmentContract workVisa sponsorshipWork visa$231.9k - $365k
...postmortem data independently, interpret results, and assess clinical significance Provide scientific leadership in defining toxicity... ...as safety department lead Contribute to developing novel biomarkers and predictive safety models Requirements ~ Doctor of...Principal- Johnson & Johnson is seeking a Senior Scientist - Data (AI) Scientist in Translational Safety to accelerate drug safety prediction using advanced AI/ML analytics... .... You will connect discovery, preclinical, clinical, and real‑world data to enable better decision making...
$173.2k - $272.6k
Job DescriptionJob Description Summary: Principal Scientist/Director, Biologics Drug Substance CommercializationJoin Our Company’s Manufacturing... .../or integrated drug substance teams supporting late-stage clinical and commercial programs, with clear line of sight to...PrincipalFull timeContract workFor contractorsLocal areaFlexible hoursMerck Sharp & Dohme (MSD)
West Point, PA4 days ago$190.8k - $300.3k
...Senior Principal Scientist leading nonclinical drug safety strategy for immunology programs at... ...regulatory submissions supporting global clinical development and registration... ...with discovery, regulatory affairs, translational medicine, and clinical development functions...Principal- ..., United States of America Job Description: Immunology Clinical Scientist Intern Our expertise in Innovative Medicine is informed... ...biomedical engineering, clinical pharmacology, clinical or translational research, computational biology, precision medicine, or similar...Full timeInternshipH1bLocal areaRemote work
$173.2k - $272.6k
...Merck seeks a Principal Scientist in Drug Metabolism and Pharmacokinetics to support multi-disciplinary... ...regulatory documents, and guiding clinical development teams in a collaborative... ..., metabolism, and clinical translation for development teams Author regulatory...Principal$117k - $201.25k
...Johnson & Johnson seeks a Principal Scientist in Operations Research and Decision Science to design... ...complex portfolio, manufacturing, and clinical supply problems. Responsibilities... ...equivalent platforms ~ Ability to translate business problems into rigorous computational...Principal$117k - $201.25k
...Johnson & Johnson seeks a Principal Scientist to design an AI-reasoning platform for translational safety in drug discovery. The role focuses on developing multimodal... ...scientific data across discovery, preclinical, clinical, and real-world evidence domains to accelerate...Principal$117k - $184.2k
...Merck's Research & Development Division seeks a Senior Scientist in bioanalytical chemistry to develop and validate mass spectrometry-based biomarkers for neuroscience drug discovery. The role focuses on translational biomarker identification for neurodegenerative...Contract work$79k - $127.65k
...Johnson Innovative Medicine is seeking a Translational Postdoctoral Researcher — Agentic AI... ...imaging, multi‑omics, and longitudinal clinical records each offer a different lens on... ...Innovative Medicine, you will work with AI scientists and translational teams across C‑BRAIN’...Temporary workFixed term contractLocal areaRemote work
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Principal Scientist, Translational Clinical Biomarkers. Be the first to apply!
