Postdoctoral Research Associate - Genetics

Position Summary We invite highly motivated candidates to apply for positions as postdoctoral fellows in the laboratory of Dr. Jeff Milbrandt in the Department of Genetics at WashU in St. Louis. Our primary goal is to unravel the mechanism of axon degeneration and its role in neurodegenerative disease. Many of our projects are pursued collaboratively with the Aaron DiAntonio lab and focus on how defects in NAD homeostasis alter disease progression in peripheral neuropathy, ALS and retinal degenerative disorders. One set of studies is aimed at determining how the NADase activity of the TIR domain protein SARM1 is regulated and how its activity influences downstream signaling pathways that control axon maintenance. Another area of interest focuses on motor neuron abnormalities that occur in ALS and in peripheral neuropathy. In particular, we are interested in the unique metabolic vulnerability of motor axons and how metabolic deficits and mitochondrial dysfunction in Schwann cells contribute to motor neuron diseases. We are also pursuing studies to define the cellular composition of peripheral nerves, particularly the microglial‑like cells that contribute to nerve homeostasis as well as disease progression. These projects utilize a wide breadth of technologies from single cell sequencing to mass spectrometry to high throughput, quantitative imaging. In addition, we use human genetics, AAV viral therapies, and disease models, including mutant mice and iPSC‑derived neurons to further understand neurodegenerative processes. These projects are funded by multiple grants from the NIH. This opportunity requires the ability to visit St. Louis for potential interviews. Job Description Primary Duties & Responsibilities: Information on being a postdoc at Washington University in St. Louis can be found at For more information on the lab please visit Working Conditions This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals. Salary Base pay is commensurate with experience. Applicant Special Instructions To apply for this position, applicants should email a single PDF file consisting of a letter of interest, a CV, and arrange for three letters of reference to be sent to Dr. Jeff Milbrandt at View email address on click.appcast.io. Education Required Qualifications: Ph.D., M.D. or equivalent terminal or doctoral degree. Preferred Qualifications: Ph.D. or M.D./Ph.D. in biological sciences or related field. No additional education unless stated elsewhere in the job posting. Certifications / Professional Licenses No specific certification/professional license is required for this position. No additional certification/professional licenses unless stated elsewhere in the job posting. Work Experience No specific work experience is required for this position. No additional work experience unless stated elsewhere in the job posting. Skills Genomics, Molecular Biology, Neuroscience. Questions For frequently asked questions about the application process, please refer to our External Applicant FAQ. Accommodation If you are unable to use our online application system and would like an accommodation, please email View email address on click.appcast.io or call the dedicated accommodation inquiry number at View phone number on click.appcast.io and leave a voicemail with the nature of your request. All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship. Pre-Employment Screening All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening. Benefits Statement Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full‑time equivalent (FTE) workload, and weekly standard hours. Please visit our website at to view a summary of benefits. EEO Statement Washington University in St. Louis is committed to the principles and practices of equal employment opportunity. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, citizenship (where prohibited by federal law), age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information. #J-18808-Ljbffr Washington University in St. Louis