Senior Director, Translational Medicine

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

To aid in this mission, the Translational Medicine team at RevMed is seeking a highly motivated, scientifically creative and collaborative Senior Director to work in a fast-paced environment within a cross-functional team. This role will report to the Head of Clinical Biomarker Development and will be leading the design and execution of clinical biomarker plans for RAS(ON) inhibitor clinical programs across solid cancer types. The position will serve as a subject-matter expert (SME) in clinical biomarker development and support clinical development strategy and programs through product life cycle.

Responsibilities:

• Lead strategic, translational thinking and contributions to early and late-stage clinical development plans.

• Represent Translational Medicine function on cross-functional teams at the program level.

• Effectively collaborate with Clinical Development, Clinical Operations, Biostatistics, Biomarker Operations and Regulatory on study design and protocol development.

• Partner with Clinical Bioinformaticians in developing biomarker analysis plans, as well as effectively collaborate with TM subfunctions of Clinical Biomarker Operations, Clinical Bioinformatics and Companion Diagnostics.

• Collaborate with Clinical Development, Biostatistics, and Medical Affairs to develop plans for publication of clinical biomarker results.

• Collaborate with Cancer Biology, Translational Research and Cancer Immunology to accelerate forward and reverse translational research.

• Keep abreast in new developments in RAS biology, predictive biomarkers, and novel molecular assays, and share knowledge with functional and cross-functional team members.

Required Skills, Experience and Education:

• A Ph.D. in cancer biology, cell/molecular biology, genomics or equivalent with 10+ years of industry experience.

• 6+ years of experience in clinical biomarker development in oncology is required.

• Development experience within oncogenic signaling pathways is required.

• Broad knowledge and understanding of established and novel technologies employed in clinical diagnostic assays (e.g. NGS, IHC, PCR) are required.

• Broad knowledge of utilizing local enrollment strategies for biomarker identification of patients.

• Excellent scientific and business communication skills, strong interpersonal/collaboration skills and planning skills.

• Ability to think critically and creatively and be able to work independently to determine appropriate resources for resolution of problems.

• Ability to multi-task and thrive in a fast-paced innovative environment.

• A great teammate, who listens effectively and invites response and discussion.

• Commitment to Revolution Medicines’ Core Values: Tireless Commitment to Patients, Transformative Science, Exceptional Together, Total Integrity, Inclusiveness and Fairness.

Preferred Skills:

• Knowledge of RAS biology and mechanism of action of RAS inhibitors is preferred.

• Prior experience within RAS-MAPK clinical development is highly desired.

• Development experience across Phase 1 and Phase 3 clinical trials is desirable.

  #LI-Hybrid #LI-EM1

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

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Base Pay Salary Range

$244,000—$305,000 USD

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