Sr Director, Disease Area Lead - Muscular Dystrophy Disease Strategy Team

Job Description General Summary: The Senior Director, BSMO (Biopharmaceutical Sciences & Manufacturing Operations) Muscular Dystrophy (MD) Disease Area Lead represents BSMO at the MD Disease Strategy Team (DST). The incumbent will provide strategic and operational leadership for all BSMO activities supporting programs within the MD DST. This role is accountable for driving an integrated BSMO program strategy, alignment, and execution across Pharmaceutical Sciences, CMTO, Quality, Supply Chain, Regulatory, Finance, and other relevant functions, to support development, launch, and lifecycle management of disease area products. As a core member of the MD DST, this leader will partner cross‑functionally to translate disease strategy into executable technical and operational plans that enable reliable, compliant delivery of medicines for patients with muscular dystrophies. By sitting on the MD DST, this role ensures alignment of BSMO priorities and resources with the broader disease area strategy, and ensures that both BSMO has appropriate visibility to the disease area on-going developments and that the DST has a clear understanding of BSMO activities and capabilities. This role reports to the Vice President, Disease Team Integration, with a dotted‑line relationship to the Vice President, Disease Area Executive – MD. Key Duties and Responsibilities: Lead the development and execution of the BSMO program strategy for MD programs, aligned with disease, clinical & commercial strategies. Serve as the BSMO representative on the MD Disease Strategy Team (DST), supporting governance, planning, and risk discussions. Provide integrated leadership across Pharmaceutical Sciences, CMTO, Quality, Supply Chain, and external partners to ensure program readiness. Partners cross-functionally within BSMO to ensure integration of plans to develop and commercialize disease area products, ensuring regulatory compliance. Support CMC regulatory strategy and submissions in partnership with Regulatory, including health authority interactions as needed. Lead cross‑functional BSMO teams to deliver against program milestones in a matrixed environment, which requires having a robust understanding of the role of each BSMO function. Build effective partnerships with internal stakeholders, both within BSMO and more broadly across Vertex. Identify and manage program‑level technical, operational, and supply risks, ensuring appropriate escalation and mitigation planning. Own BSMO program budgets, forecasts, and resource plans, aligning with functional and DST priorities. Track and communicate program status, KPIs, and risks to BSMO and DST leadership. Knowledge and Skills: Advanced knowledge of manufacturing, development and/or supply. Capability to build cross-functional alignment including R&D, Pharmaceutical Sciences, Regulatory, Finance, Commercial and Manufacturing partners. Excellent verbal, written and presentation skills. Demonstrated expertise in critical thinking, influence, negotiation, problem solving, strategic thinking and leadership in a matrix environment. Demonstrated strong leadership capability. Demonstrated ability to influence areas not under direct control to achieve objectives and effectively communicate challenging goals and objectives. Education and Experience: Advanced degree in Chemistry, Chemical Engineering, Pharmaceutical Sciences, or a related discipline; PhD and/or MBA preferred. 12+ years of experience, or equivalent, in pharmaceutical development, manufacturing, and supply chain. Demonstrated experience leading cross‑functional program teams. Pay Range: $218,400 - $327,600 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at View email address on click.appcast.io Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency . Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit or follow us on Facebook, Twitter/X , LinkedIn, YouTube and Instagram. The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives. Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.