Senior Scientist I/II - Oncology

Summary The xDC Biotherapeutics group within Oncology Drug Discovery at Novartis Biomedical Research is seeking a highly motivated and collaborative Senior Scientist I/II to advance drug-conjugate discovery programs for the treatment of cancer patients. In this lab-based role, the successful candidate will apply cell and molecular biology techniques to deliver impactful data for target validation and drug optimization efforts. This role requires a strong understanding of and experience with in vitro cell-based assays for drug discovery. This individual will interact collaboratively with colleagues across Biomedical Research and will be a member of multidisciplinary project teams. This is a great opportunity to join a group dedicated to the discovery of biotherapeutics and to support advancement of drug discovery projects into the Novartis portfolio. Key Responsibilities Generates hypotheses to test, troubleshoots issues and designs and executes the next set of experiments with some input from senior lab members/manager. Works independently and as a part of a team to design, execute, and analyze in vitro experiments to profile small molecules and biologics and elucidate mechanisms of action. Executes cell and molecular biology assays (e.g. cell titer glo, flow cytometry, JESS, western blot, MSD). Cultures cells using sterile technique including genetic engineering and validation of cell lines. Uses laboratory automation equipment (liquid handlers, plate readers, dispensers) to perform screens. Maintains an organized and detailed record of all experiments. Works collaboratively across teams and trains other members of team in areas of technical expertise as needed. Clearly communicates findings and presents research to multidisciplinary project teams. Supports lab operations including management of materials, maintenance of instruments, and general lab duties. Essential Requirements BS/MS Degree in biology or related field. Minimum 5+ years of industry experience preferred. Extensive experience with cellular assay development & execution, experience with high throughput screening workflows strongly preferred. Demonstrated ability to analyze, interpret and present data in a clear manner and use data to generate new hypotheses. Highly self-motivated, collaborative team player with exceptional organizational skills and curiosity to expand and diversify skillsets. Level will commensurate with experience. Desired Requirements Understanding of drug discovery optimization processes. Experience with discovery of antibody-drug-conjugates. Compensation and Benefits The salary for this position is expected to range between $70,000 and $183,000 USD per year. The final salary offered is determined based on factors such as relevant skills and experience, and will be reviewed periodically. Salary range may be adjusted based on company and market factors. Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. Employees are also eligible for a generous time-off package including vacation, personal days, holidays and other leaves. EEO Statement The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. #J-18808-Ljbffr Novartis