Director - Nanotechnology

Overview A healthier future is what drives Genentech to innovate and continuously advance science. The newly formed Genetic Medicine Technology group in Genentech Research and Early Development (gRED) is redefining the future of cell and gene therapies with proprietary non‑viral gene delivery and gene editing platforms, including lipid nanoparticles (LNPs), piggyBac® and Cas‑CLOVER™ technologies. We are seeking a highly motivated leader with a strong technical background in nanoparticle and LNP‑mediated nucleic acid drug delivery to join our dynamic research team advancing non‑viral therapies. Responsibilities Direct efforts in developing novel non‑viral drug delivery vehicles by overseeing the nanoparticle/nanotechnology function, working closely with the head of GMT. Lead research efforts for nanoparticle formulation, analytical characterization and primary functional evaluation in the Genetic Medicines Technology group. Discover and optimize applications of novel lipids from diverse structural families for LNP‑mediated delivery of nucleic acid payloads. Co‑lead screening efforts in vitro and in vivo, collaborating with molecular and in vivo pharmacology groups to identify novel LNP formulations for optimal tissue/cell delivery. Collaborate with diverse groups across the organization including cell therapy, vector engineering, pharmacology, translational biology, immuno‑oncology, CMC, process development and small molecule experts. Study fundamental mechanisms of action such as LNP circulation, cellular uptake, endosomal escape and payload‑specific behaviors. Advance platform development for an in‑vivo therapeutic application of an LNP modality from concept through clinical validation. Analyze and interpret complex datasets, prepare clear reports and present findings in internal program meetings, cross‑functional reviews and governance forums. Lead and contribute to external publications, conference abstracts and patent filings relevant to LNP development for autoimmune, neurology and oncology indications. Qualifications Ph.D. in chemistry, engineering, bioengineering, nanotechnology, material science or a related field with 10+ years of relevant industry and academic experience. Proven experience successfully advancing a candidate to IND‑enabling studies. Expertise in nanoparticle science, especially LNP delivery systems and non‑viral gene transfer/delivery. Strong data analysis skills and familiarity with design of experiments and statistical analyses for process optimization (e.g., JMP). Excellent communication, organizational and leadership skills. Preferred: background in DNA delivery, familiarity with nucleic acid chemistry and molecular biology, experience with targeted siRNAs, liposomes or ADCs. Preferred: experience in the immunology space and with T cells. Benefits Expected salary range: $158,200 to $293,800 (based on the primary location of San Diego, CA). Actual pay will be determined by experience, qualifications, geographic location and other job‑related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. Relocation benefits are available for this job posting. EEO Statement Genentech is an equal opportunity employer. We employ, promote and otherwise treat all employees and applicants on the basis of merit, qualifications and competence. The company’s policy prohibits unlawful discrimination, including discrimination on the basis of protected veteran status, individuals with disabilities and in accordance with all federal, state, or local laws. #J-18808-Ljbffr F. Hoffmann-La Roche AG